IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v468y2010i7325d10.1038_nature09586.html
   My bibliography  Save this article

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

Author

Listed:
  • Myunggon Ko

    (Harvard Medical School, Immune Disease Institute and Program in Cellular and Molecular Medicine, Children’s Hospital Boston
    Present address: La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA (M.K., Y.H., J.A., A.R.).)

  • Yun Huang

    (Harvard Medical School, Immune Disease Institute and Program in Cellular and Molecular Medicine, Children’s Hospital Boston
    Present address: La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA (M.K., Y.H., J.A., A.R.).)

  • Anna M. Jankowska

    (Taussig Cancer Institute, Cleveland Clinic)

  • Utz J. Pape

    (Harvard Medical School, Immune Disease Institute and Program in Cellular and Molecular Medicine, Children’s Hospital Boston
    Dana-Farber Cancer Institute and Harvard School of Public Health)

  • Mamta Tahiliani

    (Harvard Medical School, Immune Disease Institute and Program in Cellular and Molecular Medicine, Children’s Hospital Boston)

  • Hozefa S. Bandukwala

    (Harvard Medical School, Immune Disease Institute and Program in Cellular and Molecular Medicine, Children’s Hospital Boston)

  • Jungeun An

    (Harvard Medical School, Immune Disease Institute and Program in Cellular and Molecular Medicine, Children’s Hospital Boston
    Present address: La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA (M.K., Y.H., J.A., A.R.).)

  • Edward D. Lamperti

    (Harvard Medical School, Immune Disease Institute and Program in Cellular and Molecular Medicine, Children’s Hospital Boston)

  • Kian Peng Koh

    (Harvard Medical School, Immune Disease Institute and Program in Cellular and Molecular Medicine, Children’s Hospital Boston)

  • Rebecca Ganetzky

    (Taussig Cancer Institute, Cleveland Clinic)

  • X. Shirley Liu

    (Dana-Farber Cancer Institute and Harvard School of Public Health)

  • L. Aravind

    (National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health)

  • Suneet Agarwal

    (Children's Hospital Boston and Dana-Farber Cancer Institute, Harvard Stem Cell Institute)

  • Jaroslaw P. Maciejewski

    (Taussig Cancer Institute, Cleveland Clinic)

  • Anjana Rao

    (Harvard Medical School, Immune Disease Institute and Program in Cellular and Molecular Medicine, Children’s Hospital Boston
    Present address: La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA (M.K., Y.H., J.A., A.R.).)

Abstract

Mutated TET in myeloid cancers Enzymes of the TET family convert 5-methylcytosine to 5-hydroxymethylcytosine (5-hmC) in DNA. Mutations in the gene encoding TET2 are common in myeloid malignancies. These disease-associated mutations are now shown to compromise TET2 catalytic activity: bone-marrow samples from patients with TET2 mutations have low levels of 5-hmC in genomic DNA, and TET2 is required for normal haematopoietic differentiation. Measurement of genomic 5-hmC levels may prove valuable as a diagnostic tool in myeloid cancers.

Suggested Citation

  • Myunggon Ko & Yun Huang & Anna M. Jankowska & Utz J. Pape & Mamta Tahiliani & Hozefa S. Bandukwala & Jungeun An & Edward D. Lamperti & Kian Peng Koh & Rebecca Ganetzky & X. Shirley Liu & L. Aravind & , 2010. "Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2," Nature, Nature, vol. 468(7325), pages 839-843, December.
    • Handle: RePEc:nat:nature:v:468:y:2010:i:7325:d:10.1038_nature09586
    DOI: 10.1038/nature09586
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature09586
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature09586?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Morten Tulstrup & Mette Soerensen & Jakob Werner Hansen & Linn Gillberg & Maria Needhamsen & Katja Kaastrup & Kristian Helin & Kaare Christensen & Joachim Weischenfeldt & Kirsten Grønbæk, 2021. "TET2 mutations are associated with hypermethylation at key regulatory enhancers in normal and malignant hematopoiesis," Nature Communications, Nature, vol. 12(1), pages 1-10, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:468:y:2010:i:7325:d:10.1038_nature09586. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.