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Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells

Author

Listed:
  • Lucia Ricci-Vitiani

    (Oncology and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena 299)

  • Roberto Pallini

    (Catholic University of Rome, Largo Francesco Vito 1)

  • Mauro Biffoni

    (Oncology and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena 299)

  • Matilde Todaro

    (University of Palermo, Via Liborio Giuffrè 5)

  • Gloria Invernici

    (U. O. Cerebrovascular Disease Cellular Neurobiology Laboratory, Fondazione IRCCS, Neurological Institute “Carlo Besta”, Via Celoria 11)

  • Tonia Cenci

    (Institute of Pathology, Catholic University of Rome, Largo Francesco Vito 1)

  • Giulio Maira

    (Catholic University of Rome, Largo Francesco Vito 1)

  • Eugenio Agostino Parati

    (U. O. Cerebrovascular Disease Cellular Neurobiology Laboratory, Fondazione IRCCS, Neurological Institute “Carlo Besta”, Via Celoria 11)

  • Giorgio Stassi

    (University of Palermo, Via Liborio Giuffrè 5
    Cellular and Molecular Oncology, Istituto di Ricovero e Cura a Carattere Scientifico Fondazione Salvatore Maugeri, Via S. Maugeri 6)

  • Luigi Maria Larocca

    (Institute of Pathology, Catholic University of Rome, Largo Francesco Vito 1)

  • Ruggero De Maria

    (Oncology and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena 299
    Mediterranean Institute of Oncology, Via Penninazzo 7, 95029, Viagrande, Catania, Italy)

Abstract

Tumour cells that supply their own blood Glioblastomas are aggressive brain cancers that are nourished by an extensive network of blood vessels. Two groups now show that glioblastoma cells can differentiate into functional endothelial cells as part of the tumour vasculature. These endothelial cells are characterized by the same genetic alterations as the glioblastoma cells and seem to be derived from glioblastoma stem-like cells. This work suggests that some putative cancer stem cells promote cancer growth both directly and indirectly, and may explain the failure of certain anti-angiogenic cancer drugs and aid the design of new therapies.

Suggested Citation

  • Lucia Ricci-Vitiani & Roberto Pallini & Mauro Biffoni & Matilde Todaro & Gloria Invernici & Tonia Cenci & Giulio Maira & Eugenio Agostino Parati & Giorgio Stassi & Luigi Maria Larocca & Ruggero De Mar, 2010. "Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells," Nature, Nature, vol. 468(7325), pages 824-828, December.
    • Handle: RePEc:nat:nature:v:468:y:2010:i:7325:d:10.1038_nature09557
    DOI: 10.1038/nature09557
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    Citations

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    Cited by:

    1. Guiraldello, Rafael T. & Martins, Marcelo L. & Mancera, Paulo F.A., 2016. "Evaluating the efficacies of Maximum Tolerated Dose and metronomic chemotherapies: A mathematical approach," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 456(C), pages 145-156.
    2. Lata Adnani & Jordan Kassouf & Brian Meehan & Cristiana Spinelli & Nadim Tawil & Ichiro Nakano & Janusz Rak, 2022. "Angiocrine extracellular vesicles impose mesenchymal reprogramming upon proneural glioma stem cells," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    3. Sree Deepthi Muthukrishnan & Riki Kawaguchi & Pooja Nair & Rachna Prasad & Yue Qin & Maverick Johnson & Qing Wang & Nathan VanderVeer-Harris & Amy Pham & Alvaro G. Alvarado & Michael C. Condro & Fuyin, 2022. "P300 promotes tumor recurrence by regulating radiation-induced conversion of glioma stem cells to vascular-like cells," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    4. Eunnyung Bae & Ping Huang & Gaёlle Müller-Greven & Dolores Hambardzumyan & Andrew Edward Sloan & Amy S. Nowacki & Nicholas Marko & Cathleen R. Carlin & Candece L. Gladson, 2022. "Integrin α3β1 promotes vessel formation of glioblastoma-associated endothelial cells through calcium-mediated macropinocytosis and lysosomal exocytosis," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    5. Ting Xie & Adi Danieli-Mackay & Mariachiara Buccarelli & Mariano Barbieri & Ioanna Papadionysiou & Q. Giorgio D’Alessandris & Claudia Robens & Nadine Übelmesser & Omkar Suhas Vinchure & Liverana Laure, 2024. "Pervasive structural heterogeneity rewires glioblastoma chromosomes to sustain patient-specific transcriptional programs," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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