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Regulation of synaptic connectivity by glia

Author

Listed:
  • Cagla Eroglu

    (Cell Biology Department)

  • Ben A. Barres

    (Stanford University Medical Center)

Abstract

The human brain contains more than 100 trillion (1014) synaptic connections, which form all of its neural circuits. Neuroscientists have long been interested in how this complex synaptic web is weaved during development and remodelled during learning and disease. Recent studies have uncovered that glial cells are important regulators of synaptic connectivity. These cells are far more active than was previously thought and are powerful controllers of synapse formation, function, plasticity and elimination, both in health and disease. Understanding how signalling between glia and neurons regulates synaptic development will offer new insight into how the nervous system works and provide new targets for the treatment of neurological diseases.

Suggested Citation

  • Cagla Eroglu & Ben A. Barres, 2010. "Regulation of synaptic connectivity by glia," Nature, Nature, vol. 468(7321), pages 223-231, November.
    • Handle: RePEc:nat:nature:v:468:y:2010:i:7321:d:10.1038_nature09612
    DOI: 10.1038/nature09612
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    Cited by:

    1. Ralda Nehme & Olli Pietiläinen & Mykyta Artomov & Matthew Tegtmeyer & Vera Valakh & Leevi Lehtonen & Christina Bell & Tarjinder Singh & Aditi Trehan & John Sherwood & Danielle Manning & Emily Peirent , 2022. "The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia," Nature Communications, Nature, vol. 13(1), pages 1-21, December.

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