IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v467y2010i7316d10.1038_nature09414.html
   My bibliography  Save this article

The ploidy conveyor of mature hepatocytes as a source of genetic variation

Author

Listed:
  • Andrew W. Duncan

    (Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Oregon Health & Science University)

  • Matthew H. Taylor

    (Oregon Health & Science University)

  • Raymond D. Hickey

    (Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Oregon Health & Science University
    Oregon Health & Science University)

  • Amy E. Hanlon Newell

    (Oregon Health & Science University)

  • Michelle L. Lenzi

    (Oregon Health & Science University)

  • Susan B. Olson

    (Oregon Health & Science University)

  • Milton J. Finegold

    (Texas Children’s Hospital, Houston, Texas 77030, USA)

  • Markus Grompe

    (Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Oregon Health & Science University)

Abstract

Polyploidy in liver cells Many liver cells are polyploid, containing 4, 8, 16 or more times the haploid chromosome complement, although the significance of the phenomenon is not known. A study in mice now shows that hepatocytes can both increase and decrease their ploidy in vivo. Ploidy reversal was previously thought to be exclusive to meiosis, but this work shows that it can also occur in normal somatic cells. Increases in ploidy occur through failed cytokinesis, and decreases as a result of multipolar mitosis. The resulting genetic heterogeneity might be advantageous following hepatic injury when 'genetically robust' cells could be selected from a pre-existing pool of diverse genotypes.

Suggested Citation

  • Andrew W. Duncan & Matthew H. Taylor & Raymond D. Hickey & Amy E. Hanlon Newell & Michelle L. Lenzi & Susan B. Olson & Milton J. Finegold & Markus Grompe, 2010. "The ploidy conveyor of mature hepatocytes as a source of genetic variation," Nature, Nature, vol. 467(7316), pages 707-710, October.
  • Handle: RePEc:nat:nature:v:467:y:2010:i:7316:d:10.1038_nature09414
    DOI: 10.1038/nature09414
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature09414
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1038/nature09414?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Ross J. Hill & Nazareno Bona & Job Smink & Hannah K. Webb & Alastair Crisp & Juan I. Garaycoechea & Gerry P. Crossan, 2024. "p53 regulates diverse tissue-specific outcomes to endogenous DNA damage in mice," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Ren Guo & Mengmeng Jiang & Gang Wang & Bing Li & Xiaohui Jia & Yan Ai & Shanshan Chen & Peilan Tang & Aijie Liu & Qianting Yuan & Xin Xie, 2022. "IL6 supports long-term expansion of hepatocytes in vitro," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:467:y:2010:i:7316:d:10.1038_nature09414. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.