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Dissection of genetically complex traits with extremely large pools of yeast segregants

Author

Listed:
  • Ian M. Ehrenreich

    (Lewis-Sigler Institute for Integrative Genomics,
    Department of Ecology and Evolutionary Biology,
    Howard Hughes Medical Institute,)

  • Noorossadat Torabi

    (Lewis-Sigler Institute for Integrative Genomics,
    Princeton University, Princeton, New Jersey 08540, USA)

  • Yue Jia

    (Lewis-Sigler Institute for Integrative Genomics,
    Howard Hughes Medical Institute,)

  • Jonathan Kent

    (Lewis-Sigler Institute for Integrative Genomics,)

  • Stephen Martis

    (Lewis-Sigler Institute for Integrative Genomics,)

  • Joshua A. Shapiro

    (Lewis-Sigler Institute for Integrative Genomics,
    Department of Ecology and Evolutionary Biology,
    Howard Hughes Medical Institute,)

  • David Gresham

    (Lewis-Sigler Institute for Integrative Genomics,
    Present address: Center for Genomics and Systems Biology, New York University, New York, New York 10003, USA.)

  • Amy A. Caudy

    (Lewis-Sigler Institute for Integrative Genomics,)

  • Leonid Kruglyak

    (Lewis-Sigler Institute for Integrative Genomics,
    Department of Ecology and Evolutionary Biology,
    Howard Hughes Medical Institute,)

Abstract

Complex traits made simple in yeast Discovering genetic basis of complex traits remains one of key challenges of today's genetic research. Current approaches cannot identify multiple loci with small effects because of the lack of statistical power. Ehrenreich et al. have developed a method that overcomes this problem. Working in yeast they use chemical resistance traits and mitochondrial function to demonstrate genetic complexity of many traits and that many of the underlying factors can be identified using their approach, which ultimately could be extended to other organisms.

Suggested Citation

  • Ian M. Ehrenreich & Noorossadat Torabi & Yue Jia & Jonathan Kent & Stephen Martis & Joshua A. Shapiro & David Gresham & Amy A. Caudy & Leonid Kruglyak, 2010. "Dissection of genetically complex traits with extremely large pools of yeast segregants," Nature, Nature, vol. 464(7291), pages 1039-1042, April.
    • Handle: RePEc:nat:nature:v:464:y:2010:i:7291:d:10.1038_nature08923
    DOI: 10.1038/nature08923
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    Cited by:

    1. Hyosik Jang & Ian M Ehrenreich, 2012. "Genome-Wide Characterization of Genetic Variation in the Unicellular, Green Alga Chlamydomonas reinhardtii," PLOS ONE, Public Library of Science, vol. 7(7), pages 1-9, July.

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