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A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity

Author

Listed:
  • Rosa M. Marión

    (Telomeres and Telomerase Group,)

  • Katerina Strati

    (Telomeres and Telomerase Group,)

  • Han Li

    (Tumor Suppression Group,)

  • Matilde Murga

    (Genetic Instability Group, Molecular Oncology Program, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, Madrid E-28029, Spain)

  • Raquel Blanco

    (Telomeres and Telomerase Group,)

  • Sagrario Ortega

    (Transgenic mice Unit, Biotechnology Program, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, Madrid E-28029, Spain)

  • Oscar Fernandez-Capetillo

    (Genetic Instability Group, Molecular Oncology Program, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, Madrid E-28029, Spain)

  • Manuel Serrano

    (Tumor Suppression Group,)

  • Maria A. Blasco

    (Telomeres and Telomerase Group,)

Abstract

On iPS cells and p53: reprogramming DNA damage responses Marión et al. show that p53 is critically involved in preventing the reprogramming of cells carrying various types of DNA damage, including short telomeres, DNA repair deficiencies, or with exogenously inflicted DNA damage. Eliminating p53 expression allows efficient reprogramming in the face of DNA damage and the generation of iPS cells carrying persistent DNA damage and chromosomal aberrations. They conclude that p53 is critical in preventing the generation of pluripotent cells from suboptimal parental cells.

Suggested Citation

  • Rosa M. Marión & Katerina Strati & Han Li & Matilde Murga & Raquel Blanco & Sagrario Ortega & Oscar Fernandez-Capetillo & Manuel Serrano & Maria A. Blasco, 2009. "A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity," Nature, Nature, vol. 460(7259), pages 1149-1153, August.
    • Handle: RePEc:nat:nature:v:460:y:2009:i:7259:d:10.1038_nature08287
    DOI: 10.1038/nature08287
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    Cited by:

    1. Tomoe Ueyama & Shu Nakao & Tasuku Tsukamoto & Dai Ihara & Yukihiro Harada & Yuka Akagi & Sae Nakagawa & Teruhisa Kawamura & Takahiro Sogo & Yasuyuki S Kida, 2018. "PTEN/Akt Axis is Involved in Somatic Cell Reprogramming to Mouse iPS Cells," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 11(5), pages 8789-8795, December.

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