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Neurotransmission selectively regulates synapse formation in parallel circuits in vivo

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  • Daniel Kerschensteiner

    (Washington University School of Medicine, St Louis, Missouri 63110, USA
    Department of Biological Structure,
    Present Address: Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA.)

  • Josh L. Morgan

    (Washington University School of Medicine, St Louis, Missouri 63110, USA
    Department of Biological Structure,)

  • Edward D. Parker

    (University of Washington, Seattle, Washington 98195, USA)

  • Renate M. Lewis

    (Washington University School of Medicine, St Louis, Missouri 63110, USA)

  • Rachel O. L. Wong

    (Washington University School of Medicine, St Louis, Missouri 63110, USA
    Department of Biological Structure,)

Abstract

Activity-dependent synapse formation Activity is presumed to help shape the connectivity within neural circuits, with differences often leading to the elimination of less active connections. Here, to challenge this notion, a subpopulation of bipolar cells was inactivated during development, yet retinal ganglion cells still received input from them, albeit through fewer synapses. This occurred through a reduced rate of synapse formation rather than an increase in synapse elimination. Synaptogenesis and connectivity within a parallel processing stream of bipolar cell input converging onto the same retinal ganglion cell were unaffected. These observations reveal an unexpected and independent role for activity in regulating the rate of synapse formation rather than elimination for specific set of inputs during circuit formation in vivo.

Suggested Citation

  • Daniel Kerschensteiner & Josh L. Morgan & Edward D. Parker & Renate M. Lewis & Rachel O. L. Wong, 2009. "Neurotransmission selectively regulates synapse formation in parallel circuits in vivo," Nature, Nature, vol. 460(7258), pages 1016-1020, August.
    • Handle: RePEc:nat:nature:v:460:y:2009:i:7258:d:10.1038_nature08236
    DOI: 10.1038/nature08236
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    Cited by:

    1. Donald R Cantrell & Jianhua Cang & John B Troy & Xiaorong Liu, 2010. "Non-Centered Spike-Triggered Covariance Analysis Reveals Neurotrophin-3 as a Developmental Regulator of Receptive Field Properties of ON-OFF Retinal Ganglion Cells," PLOS Computational Biology, Public Library of Science, vol. 6(10), pages 1-16, October.

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