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Emerging roles for lipids in shaping membrane-protein function

Author

Listed:
  • Rob Phillips

    (California Institute of Technology)

  • Tristan Ursell

    (California Institute of Technology)

  • Paul Wiggins

    (Whitehead Institute of Biomedical Research)

  • Pierre Sens

    (UMR Gulliver CNRS-ESPCI)

Abstract

Studies of membrane proteins have revealed a direct link between the lipid environment and the structure and function of some of these proteins. Although some of these effects involve specific chemical interactions between lipids and protein residues, many can be understood in terms of protein-induced perturbations to the membrane shape. The free-energy cost of such perturbations can be estimated quantitatively, and measurements of channel gating in model systems of membrane proteins with their lipid partners are now confirming predictions of simple models.

Suggested Citation

  • Rob Phillips & Tristan Ursell & Paul Wiggins & Pierre Sens, 2009. "Emerging roles for lipids in shaping membrane-protein function," Nature, Nature, vol. 459(7245), pages 379-385, May.
    • Handle: RePEc:nat:nature:v:459:y:2009:i:7245:d:10.1038_nature08147
    DOI: 10.1038/nature08147
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    Cited by:

    1. Eri Takematsu & Miles Massidda & Jeff Auster & Po-Chih Chen & ByungGee Im & Sanjana Srinath & Sophia Canga & Aditya Singh & Marjan Majid & Michael Sherman & Andrew Dunn & Annette Graham & Patricia Mar, 2022. "Transmembrane stem cell factor protein therapeutics enhance revascularization in ischemia without mast cell activation," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Anne M. Kiirikki & Hanne S. Antila & Lara S. Bort & Pavel Buslaev & Fernando Favela-Rosales & Tiago Mendes Ferreira & Patrick F. J. Fuchs & Rebeca Garcia-Fandino & Ivan Gushchin & Batuhan Kav & Norber, 2024. "Overlay databank unlocks data-driven analyses of biomolecules for all," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    3. Carlos A. Z. Bassetto & Juergen Pfeffermann & Rohit Yadav & Simon Strassgschwandtner & Toma Glasnov & Francisco Bezanilla & Peter Pohl, 2024. "Photolipid excitation triggers depolarizing optocapacitive currents and action potentials," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    4. Yining Jiang & Batiste Thienpont & Vinay Sapuru & Richard K. Hite & Jeremy S. Dittman & James N. Sturgis & Simon Scheuring, 2022. "Membrane-mediated protein interactions drive membrane protein organization," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    5. Alexander P. Fellows & Ben John & Martin Wolf & Martin Thämer, 2024. "Spiral packing and chiral selectivity in model membranes probed by phase-resolved sum-frequency generation microscopy," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    6. Zhongjie Ye & Nicola Galvanetto & Leonardo Puppulin & Simone Pifferi & Holger Flechsig & Melanie Arndt & Cesar Adolfo Sánchez Triviño & Michael Palma & Shifeng Guo & Horst Vogel & Anna Menini & Clemen, 2024. "Structural heterogeneity of the ion and lipid channel TMEM16F," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    7. Yangang Pan & Jingyu Zhan & Yining Jiang & Di Xia & Simon Scheuring, 2023. "A concerted ATPase cycle of the protein transporter AAA-ATPase Bcs1," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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