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Association of reactive oxygen species levels and radioresistance in cancer stem cells

Author

Listed:
  • Maximilian Diehn

    (Department of Radiation Oncology,
    Stanford Institute for Stem Cell Biology and Regenerative Medicine,)

  • Robert W. Cho

    (Stanford Institute for Stem Cell Biology and Regenerative Medicine,
    Department of Pediatrics Division of Stem Cell Transplantation,)

  • Neethan A. Lobo

    (Stanford Institute for Stem Cell Biology and Regenerative Medicine,)

  • Tomer Kalisky

    (Stanford University, Stanford, California 94305, USA)

  • Mary Jo Dorie

    (Department of Radiation Oncology,)

  • Angela N. Kulp

    (Stanford Institute for Stem Cell Biology and Regenerative Medicine,)

  • Dalong Qian

    (Stanford Institute for Stem Cell Biology and Regenerative Medicine,)

  • Jessica S. Lam

    (Stanford Institute for Stem Cell Biology and Regenerative Medicine,)

  • Laurie E. Ailles

    (Stanford Institute for Stem Cell Biology and Regenerative Medicine,)

  • Manzhi Wong

    (Stanford Institute for Stem Cell Biology and Regenerative Medicine,)

  • Benzion Joshua

    (Department of Otolaryngology—Head and Neck Surgery,)

  • Michael J. Kaplan

    (Department of Otolaryngology—Head and Neck Surgery,)

  • Irene Wapnir

    (Department of Surgery,)

  • Frederick M. Dirbas

    (Department of Surgery,)

  • George Somlo

    (Department of Medical Oncology and Therapeutics Research,)

  • Carlos Garberoglio

    (Department of Surgery,)

  • Benjamin Paz

    (Department of Surgery,)

  • Jeannie Shen

    (Department of Surgery,)

  • Sean K. Lau

    (City of Hope National Medical Center, Duarte, California, California 91010, USA)

  • Stephen R. Quake

    (Stanford University, Stanford, California 94305, USA)

  • J. Martin Brown

    (Department of Radiation Oncology,)

  • Irving L. Weissman

    (Stanford Institute for Stem Cell Biology and Regenerative Medicine,
    Departments of Pathology and Developmental Biology,)

  • Michael F. Clarke

    (Stanford Institute for Stem Cell Biology and Regenerative Medicine,
    Stanford University School of Medicine, Stanford, California 94305, USA)

Abstract

Reactive oxygen: role in tumour radiation resistance Michael Clarke and colleagues find that cancer stem cell in breast tumours have lower levels of reactive oxygen species (ROS) than the rest of the tumour cells. This property renders cancer stem cells less sensitive to radiation therapy, which may cause radio resistance in breast cancer.

Suggested Citation

  • Maximilian Diehn & Robert W. Cho & Neethan A. Lobo & Tomer Kalisky & Mary Jo Dorie & Angela N. Kulp & Dalong Qian & Jessica S. Lam & Laurie E. Ailles & Manzhi Wong & Benzion Joshua & Michael J. Kaplan, 2009. "Association of reactive oxygen species levels and radioresistance in cancer stem cells," Nature, Nature, vol. 458(7239), pages 780-783, April.
    • Handle: RePEc:nat:nature:v:458:y:2009:i:7239:d:10.1038_nature07733
    DOI: 10.1038/nature07733
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    Citations

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    Cited by:

    1. Sherin Saheera & Renuka R Nair, 2017. "Accelerated decline in cardiac stem cell efficiency in Spontaneously hypertensive rat compared to normotensive Wistar rat," PLOS ONE, Public Library of Science, vol. 12(12), pages 1-17, December.
    2. Peter Kovacic & Ratnasamy Somanathan, 2017. "Unifying Mechanism for Nutrients as Anticancer Agents: Electron Transfer, Reactive Oxygen Species and Oxidative Stress," Global Journal of Health Science, Canadian Center of Science and Education, vol. 9(8), pages 1-66, August.

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