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Genes mirror geography within Europe

Author

Listed:
  • John Novembre

    (University of California–Los Angeles, Los Angeles, California 90095, USA
    Department of Human Genetics,)

  • Toby Johnson

    (Department of Medical Genetics,
    University Institute for Social and Preventative Medecine, Centre Hospitalier Universitaire Vaudois (CHUV), University of Lausanne, Rue de Bugnon 27 - DGM 328, CH-1005 Lausanne, Switzerland
    Swiss Institute of Bioinformatics, Central Administration, Quartier Sorge - Batiment Genopode, 1015 Lausanne, Switzerland)

  • Katarzyna Bryc

    (Cornell University, Ithaca, New York 14853, USA)

  • Zoltán Kutalik

    (Department of Medical Genetics,
    Swiss Institute of Bioinformatics, Central Administration, Quartier Sorge - Batiment Genopode, 1015 Lausanne, Switzerland)

  • Adam R. Boyko

    (Cornell University, Ithaca, New York 14853, USA)

  • Adam Auton

    (Cornell University, Ithaca, New York 14853, USA)

  • Amit Indap

    (Cornell University, Ithaca, New York 14853, USA)

  • Karen S. King

    (GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA)

  • Sven Bergmann

    (Department of Medical Genetics,
    Swiss Institute of Bioinformatics, Central Administration, Quartier Sorge - Batiment Genopode, 1015 Lausanne, Switzerland)

  • Matthew R. Nelson

    (GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA)

  • Matthew Stephens

    (Department of Human Genetics,
    University of Chicago, Chicago, Illinois 60637, USA)

  • Carlos D. Bustamante

    (Cornell University, Ithaca, New York 14853, USA)

Abstract

Ethnic variation in the genes The power of the latest massively parallel synthetic DNA sequencing technologies is demonstrated in two major collaborations that shed light on the nature of genomic variation with ethnicity. The first describes the genomic characterization of an individual from the Yoruba ethnic group of west Africa. The second reports a personal genome of a Han Chinese, the group comprising 30% of the world's population. These new resources can now be used in conjunction with the Venter, Watson and NIH reference sequences. A separate study looked at genetic ethnicity on the continental scale, based on data from 1,387 individuals from more than 30 European countries. Overall there was little genetic variation between countries, but the differences that do exist correspond closely to the geographic map. Statistical analysis of the genome data places 50% of the individuals within 310 km of their reported origin. As well as its relevance for testing genetic ancestry, this work has implications for evaluating genome-wide association studies that link genes with diseases.

Suggested Citation

  • John Novembre & Toby Johnson & Katarzyna Bryc & Zoltán Kutalik & Adam R. Boyko & Adam Auton & Amit Indap & Karen S. King & Sven Bergmann & Matthew R. Nelson & Matthew Stephens & Carlos D. Bustamante, 2008. "Genes mirror geography within Europe," Nature, Nature, vol. 456(7218), pages 98-101, November.
    • Handle: RePEc:nat:nature:v:456:y:2008:i:7218:d:10.1038_nature07331
    DOI: 10.1038/nature07331
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