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The development of allergic inflammation

Author

Listed:
  • Stephen J. Galli

    (Stanford University School of Medicine
    Stanford University School of Medicine)

  • Mindy Tsai

    (Stanford University School of Medicine)

  • Adrian M. Piliponsky

    (Stanford University School of Medicine)

Abstract

Allergic disorders, such as anaphylaxis, hay fever, eczema and asthma, now afflict roughly 25% of people in the developed world. In allergic subjects, persistent or repetitive exposure to allergens, which typically are intrinsically innocuous substances common in the environment, results in chronic allergic inflammation. This in turn produces long-term changes in the structure of the affected organs and substantial abnormalities in their function. It is therefore important to understand the characteristics and consequences of acute and chronic allergic inflammation, and in particular to explore how mast cells can contribute to several features of this maladaptive pattern of immunological reactivity.

Suggested Citation

  • Stephen J. Galli & Mindy Tsai & Adrian M. Piliponsky, 2008. "The development of allergic inflammation," Nature, Nature, vol. 454(7203), pages 445-454, July.
    • Handle: RePEc:nat:nature:v:454:y:2008:i:7203:d:10.1038_nature07204
    DOI: 10.1038/nature07204
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    Cited by:

    1. Anamika Basu, 2022. "In Silico Epitope-Based Vaccine Prediction against Fungal Infection Aspergillosis," Challenges, MDPI, vol. 13(2), pages 1-15, July.
    2. Thao Thi Thu Nguyen & Tomomi Higashi & Yasuhiro Kambayashi & Enoch Olando Anyenda & Yoshimasa Michigami & Johsuke Hara & Masaki Fujimura & Hiromasa Tsujiguchi & Masami Kitaoka & Hiroki Asakura & Daisu, 2016. "A Longitudinal Study of Association between Heavy Metals and Itchy Eyes, Coughing in Chronic Cough Patients: Related with Non-Immunoglobulin E Mediated Mechanism," IJERPH, MDPI, vol. 13(1), pages 1-14, January.
    3. Michela Franchini & Stefania Pieroni & Nicola Martini & Andrea Ripoli & Dante Chiappino & Francesca Denoth & Michael Norman Liebman & Sabrina Molinaro & Daniele Della Latta, 2020. "Shifting the Paradigm: The Dress-COV Telegram Bot as a Tool for Participatory Medicine," IJERPH, MDPI, vol. 17(23), pages 1-19, November.
    4. Hans Oh & Ai Koyanagi & Jordan E. DeVylder & Andrew Stickley, 2018. "Seasonal Allergies and Psychiatric Disorders in the United States," IJERPH, MDPI, vol. 15(9), pages 1-12, September.
    5. Rachel Drawbond & Kathrin Spendier, 2019. "TIRF Microscope Image Sequences of Fluorescent IgE-FcεRI Receptor Complexes inside a FcεRI-Centric Synapse in RBL-2H3 Cells," Data, MDPI, vol. 4(3), pages 1-11, July.
    6. Snezna Sodin-Semrl & Katja Lakota & Jean Dubuisson & Bridget Ellul & Antony Fenech & José Joaquín Ceron Madrigal & Gerhard Thallinger & Mauro Perretti & Fulvio d’Acquisto & John Raynes & Francisco Rom, 2011. "CODI-STRAT – An Interdisciplinary Network Geared towards Sustainable Management of Chronic and Infective Diseases," MIC 2011: Managing Sustainability? Proceedings of the 12th International Conference, Portorož, 23–26 November 2011 [Selected Papers],, University of Primorska, Faculty of Management Koper.

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