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Drosophila Pgc protein inhibits P-TEFb recruitment to chromatin in primordial germ cells

Author

Listed:
  • Kazuko Hanyu-Nakamura

    (Laboratory for Germline Development, RIKEN Center for Developmental Biology, Kobe, Hyogo 650-0047, Japan)

  • Hiroko Sonobe-Nojima

    (Laboratory for Germline Development, RIKEN Center for Developmental Biology, Kobe, Hyogo 650-0047, Japan)

  • Akie Tanigawa

    (Laboratory for Germline Development, RIKEN Center for Developmental Biology, Kobe, Hyogo 650-0047, Japan)

  • Paul Lasko

    (McGill University, Montreal, Quebec H3A 1B1, Canada)

  • Akira Nakamura

    (Laboratory for Germline Development, RIKEN Center for Developmental Biology, Kobe, Hyogo 650-0047, Japan)

Abstract

The gene polar granule component (pgc) has been implicated in the global repression of transcription that occurs in Drosophila germline progenitors and was thought to act as a non-coding RNA. This paper shows that pgc encodes a small protein that represses transcription by preventing recruitment of the elongation factor P-TEFb.

Suggested Citation

  • Kazuko Hanyu-Nakamura & Hiroko Sonobe-Nojima & Akie Tanigawa & Paul Lasko & Akira Nakamura, 2008. "Drosophila Pgc protein inhibits P-TEFb recruitment to chromatin in primordial germ cells," Nature, Nature, vol. 451(7179), pages 730-733, February.
  • Handle: RePEc:nat:nature:v:451:y:2008:i:7179:d:10.1038_nature06498
    DOI: 10.1038/nature06498
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    Cited by:

    1. Pedro Patraquim & Emile G. Magny & José I. Pueyo & Ana Isabel Platero & Juan Pablo Couso, 2022. "Translation and natural selection of micropeptides from long non-canonical RNAs," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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