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NUMB controls p53 tumour suppressor activity

Author

Listed:
  • Ivan N. Colaluca

    (IFOM, the FIRC Institute for Molecular Oncology Foundation, Via Adamello 16, 20139, Milan, Italy
    European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy)

  • Daniela Tosoni

    (IFOM, the FIRC Institute for Molecular Oncology Foundation, Via Adamello 16, 20139, Milan, Italy
    European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy)

  • Paolo Nuciforo

    (IFOM, the FIRC Institute for Molecular Oncology Foundation, Via Adamello 16, 20139, Milan, Italy)

  • Francesca Senic-Matuglia

    (IFOM, the FIRC Institute for Molecular Oncology Foundation, Via Adamello 16, 20139, Milan, Italy)

  • Viviana Galimberti

    (European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy)

  • Giuseppe Viale

    (European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Chirurgia ed Odontoiatria, Università degli Studi di Milano)

  • Salvatore Pece

    (IFOM, the FIRC Institute for Molecular Oncology Foundation, Via Adamello 16, 20139, Milan, Italy
    European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Chirurgia ed Odontoiatria, Università degli Studi di Milano)

  • Pier Paolo Di Fiore

    (IFOM, the FIRC Institute for Molecular Oncology Foundation, Via Adamello 16, 20139, Milan, Italy
    European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Chirurgia ed Odontoiatria, Università degli Studi di Milano)

Abstract

NUMB's anticancer action The NUMB protein is involved in cell fate decisions via an interaction with a NOTCH family plasma membrane receptor, and plays a role in endocytosis. Its expression was known to be downregulated in human breast cancers. Now NUMB has been found to act as a tumour suppressor protein by inhibiting the ubiquitin ligase HDM2, thereby preventing the destruction of the major tumour suppressor p53. In addition, low levels of NUMB expression in breast tumours are found to be associated with a poor prognosis. These findings connect two areas of cell biology previously considered unrelated, and are of potential relevance for the design of rational therapies for cancer.

Suggested Citation

  • Ivan N. Colaluca & Daniela Tosoni & Paolo Nuciforo & Francesca Senic-Matuglia & Viviana Galimberti & Giuseppe Viale & Salvatore Pece & Pier Paolo Di Fiore, 2008. "NUMB controls p53 tumour suppressor activity," Nature, Nature, vol. 451(7174), pages 76-80, January.
    • Handle: RePEc:nat:nature:v:451:y:2008:i:7174:d:10.1038_nature06412
    DOI: 10.1038/nature06412
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    Cited by:

    1. Yong-Jun Shin & Ali H Sayed & Xiling Shen, 2012. "Adaptive Models for Gene Networks," PLOS ONE, Public Library of Science, vol. 7(2), pages 1-6, February.

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