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The effects of molecular noise and size control on variability in the budding yeast cell cycle

Author

Listed:
  • Stefano Di Talia

    (The Rockefeller University
    Center for Studies in Physics and Biology, The Rockefeller University, New York, New York 10021, USA)

  • Jan M. Skotheim

    (Center for Studies in Physics and Biology, The Rockefeller University, New York, New York 10021, USA)

  • James M. Bean

    (The Rockefeller University
    Present address: Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.)

  • Eric D. Siggia

    (Center for Studies in Physics and Biology, The Rockefeller University, New York, New York 10021, USA)

  • Frederick R. Cross

    (The Rockefeller University)

Abstract

Reports on single cell experiments in budding yeast that analyse the role of molecular noise during the G1 phase of the cell cycle. Variability in the timing of G1 can be attributed to variations in cell size at cell birth, as well as variations of a size-independent 'timer' step. These two steps are modular and together control the timing of the critical Start transition of the G1 phase.

Suggested Citation

  • Stefano Di Talia & Jan M. Skotheim & James M. Bean & Eric D. Siggia & Frederick R. Cross, 2007. "The effects of molecular noise and size control on variability in the budding yeast cell cycle," Nature, Nature, vol. 448(7156), pages 947-951, August.
    • Handle: RePEc:nat:nature:v:448:y:2007:i:7156:d:10.1038_nature06072
    DOI: 10.1038/nature06072
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    Cited by:

    1. Chengjun Cao & Keyi Wang & Yina Wang & Tong-Bao Liu & Amariliz Rivera & Chaoyang Xue, 2022. "Ubiquitin proteolysis of a CDK-related kinase regulates titan cell formation and virulence in the fungal pathogen Cryptococcus neoformans," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Andreas P. Cuny & K. Tanuj Sapra & David Martinez-Martin & Gotthold Fläschner & Jonathan D. Adams & Sascha Martin & Christoph Gerber & Fabian Rudolf & Daniel J. Müller, 2022. "High-resolution mass measurements of single budding yeast reveal linear growth segments," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    3. G. Yahya & P. Menges & P. S. Amponsah & D. A. Ngandiri & D. Schulz & A. Wallek & N. Kulak & M. Mann & P. Cramer & V. Savage & M. Räschle & Z. Storchova, 2022. "Sublinear scaling of the cellular proteome with ploidy," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    4. Andreas Doncic & Umut Eser & Oguzhan Atay & Jan M Skotheim, 2013. "An Algorithm to Automate Yeast Segmentation and Tracking," PLOS ONE, Public Library of Science, vol. 8(3), pages 1-11, March.
    5. Dola Sengupta & Sandip Kar, 2015. "Are Quasi-Steady-State Approximated Models Suitable for Quantifying Intrinsic Noise Accurately?," PLOS ONE, Public Library of Science, vol. 10(9), pages 1-24, September.

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