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The common biology of cancer and ageing

Author

Listed:
  • Toren Finkel

    (Cardiology Branch, NIH, NHLBI, Building 10/CRC 5-3330, 10 Center Drive, Bethesda, Maryland 20892, USA)

  • Manuel Serrano

    (Spanish National Cancer Research Center (CNIO) 3 Melchor Fernandez Almagro Street, Madrid 28029, Spain)

  • Maria A. Blasco

    (Spanish National Cancer Research Center (CNIO) 3 Melchor Fernandez Almagro Street, Madrid 28029, Spain)

Abstract

Cancer and ageing The peculiar form of immortality displayed by cancer cells and the ageing process that contributes to our mortality would seem to be opposites. But remarkably, the underlying biology of cancerous cells and ageing have converged. Genomic instability, telomere function and autophagy feature in papers on both cancer and ageing. Connections have emerged between tumorigenesis and cell senescence. And mitochondrial metabolism is key to both phenomena. Finkel et al. present a historical perspective of the common biology of cancer and ageing, from the first realization that human cancer cells — HeLa cells — could divide continuously in culture to the dawn of the systems biology approach.

Suggested Citation

  • Toren Finkel & Manuel Serrano & Maria A. Blasco, 2007. "The common biology of cancer and ageing," Nature, Nature, vol. 448(7155), pages 767-774, August.
    • Handle: RePEc:nat:nature:v:448:y:2007:i:7155:d:10.1038_nature05985
    DOI: 10.1038/nature05985
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    Cited by:

    1. Elena Martínez-Balsalobre & Jesús García-Castillo & Diana García-Moreno & Elena Naranjo-Sánchez & Miriam Fernández-Lajarín & María A. Blasco & Francisca Alcaraz-Pérez & Victoriano Mulero & María L. Ca, 2023. "Telomerase RNA-based aptamers restore defective myelopoiesis in congenital neutropenic syndromes," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Johannes Klotz & Monika Hackl & Markus Schwab & Alexander Hanika & Daniela Haluza, 2019. "Combining population projections with quasi-likelihood models: A new way to predict cancer incidence and cancer mortality in Austria up to 2030," Demographic Research, Max Planck Institute for Demographic Research, Rostock, Germany, vol. 40(19), pages 503-532.
    3. Kazumasa Yamada, 2019. "An Acquaintance with An Aging Society," Social Sciences, MDPI, vol. 8(4), pages 1-27, April.
    4. Lee Liu & Kristen Liu, 2016. "Age-specific cancer mortality trends in 16 countries," International Journal of Public Health, Springer;Swiss School of Public Health (SSPH+), vol. 61(7), pages 751-763, September.

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