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Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging

Author

Listed:
  • Jianping Jin

    (Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA)

  • Xue Li

    (Harvard Medical School, 200 Longwood Drive, Boston, Massachusetts 02115, USA)

  • Steven P. Gygi

    (Harvard Medical School, 200 Longwood Drive, Boston, Massachusetts 02115, USA)

  • J. Wade Harper

    (Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA)

Abstract

A divergent E1 in vertebrates and sea urchin, Uba6, is identified, which specifically activates ubiquitin but not other ubiquitin-like proteins in vitro and in vivo. Human Uba6 and Ube1 have distinct preferences for E2 charging in vitro, and their specificity depends in part on their C-terminal ubiquitin-fold domains, which recruit E2s.

Suggested Citation

  • Jianping Jin & Xue Li & Steven P. Gygi & J. Wade Harper, 2007. "Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging," Nature, Nature, vol. 447(7148), pages 1135-1138, June.
    • Handle: RePEc:nat:nature:v:447:y:2007:i:7148:d:10.1038_nature05902
    DOI: 10.1038/nature05902
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    Cited by:

    1. Iona Wallace & Kheewoong Baek & J. Rajan Prabu & Ronnald Vollrath & Susanne Gronau & Brenda A. Schulman & Kirby N. Swatek, 2023. "Insights into the ISG15 transfer cascade by the UBE1L activating enzyme," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Shuo-Shuo Liu & Tian-Xia Jiang & Fan Bu & Ji-Lan Zhao & Guang-Fei Wang & Guo-Heng Yang & Jie-Yan Kong & Yun-Fan Qie & Pei Wen & Li-Bin Fan & Ning-Ning Li & Ning Gao & Xiao-Bo Qiu, 2024. "Molecular mechanisms underlying the BIRC6-mediated regulation of apoptosis and autophagy," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    3. Ngoc Truongvan & Shurong Li & Mohit Misra & Monika Kuhn & Hermann Schindelin, 2022. "Structures of UBA6 explain its dual specificity for ubiquitin and FAT10," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    4. Lingmin Yuan & Fei Gao & Zongyang Lv & Digant Nayak & Anindita Nayak & Priscila dos Santos Bury & Kristin E. Cano & Lijia Jia & Natalia Oleinik & Firdevs Cansu Atilgan & Besim Ogretmen & Katelyn M. Wi, 2022. "Crystal structures reveal catalytic and regulatory mechanisms of the dual-specificity ubiquitin/FAT10 E1 enzyme Uba6," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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