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Resolvin E1 and protectin D1 activate inflammation-resolution programmes

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  • Jan M. Schwab

    (Center for Experimental Therapeutics and Reperfusion Injury, Perioperative and Pain Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Present addresses: Klinik und Poliklinik für Neurologie & Experimentelle Neurologie, Campus-Mitte, Charité Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany (J.M.S.); Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan (M.A.).)

  • Nan Chiang

    (Center for Experimental Therapeutics and Reperfusion Injury, Perioperative and Pain Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Makoto Arita

    (Center for Experimental Therapeutics and Reperfusion Injury, Perioperative and Pain Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Present addresses: Klinik und Poliklinik für Neurologie & Experimentelle Neurologie, Campus-Mitte, Charité Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany (J.M.S.); Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan (M.A.).)

  • Charles N. Serhan

    (Center for Experimental Therapeutics and Reperfusion Injury, Perioperative and Pain Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA)

Abstract

This paper examines the role of lipid metabolites of arachidonic acid, docosahexaenoic acid and eicosapentaenoic acid in the resolution of acute inflammation. The omega-3 fatty acids are shown to affect phagocytosis, phagocyte removal, and leukocyte infiltration.

Suggested Citation

  • Jan M. Schwab & Nan Chiang & Makoto Arita & Charles N. Serhan, 2007. "Resolvin E1 and protectin D1 activate inflammation-resolution programmes," Nature, Nature, vol. 447(7146), pages 869-874, June.
    • Handle: RePEc:nat:nature:v:447:y:2007:i:7146:d:10.1038_nature05877
    DOI: 10.1038/nature05877
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    Cited by:

    1. Daniela Pasotto & Liesel van Emmenes & Marco Cullere & Valerio Giaccone & Elsje Pieterse & Louwrens Christiaan Hoffman & Antonella Dalle Zotte, 2020. "Inclusion of Hermetia illucens larvae reared on fish offal to the diet of broiler quails: Effect on immunity and caecal microbial populations," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 65(6), pages 213-223.

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