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Unproductive splicing of SR genes associated with highly conserved and ultraconserved DNA elements

Author

Listed:
  • Liana F. Lareau

    (Departments of Molecular and Cell Biology and,)

  • Maki Inada

    (Plant and Microbial Biology, University of California, Berkeley, California 94720, USA)

  • Richard E. Green

    (Departments of Molecular and Cell Biology and,
    Present address: Max Planck Institute for Evolutionary Anthropology, Leipzig D-04103, Germany.)

  • Jordan C. Wengrod

    (Departments of Molecular and Cell Biology and,)

  • Steven E. Brenner

    (Departments of Molecular and Cell Biology and,
    Plant and Microbial Biology, University of California, Berkeley, California 94720, USA)

Abstract

A function is defined for ultraconserved elements (UCEs), extragenic regions of eukaryotic genomes can show high degrees of conservation across species. It is also found that when alternative splicing (mediated by splicing regulator proteins) leads to UCE incorporation into the splicing regulator protein's mRNA, the mRNA is targeted for degradation. Thus, the UCEs help promote negative feedback regulation of the splicing regulator gene expression.

Suggested Citation

  • Liana F. Lareau & Maki Inada & Richard E. Green & Jordan C. Wengrod & Steven E. Brenner, 2007. "Unproductive splicing of SR genes associated with highly conserved and ultraconserved DNA elements," Nature, Nature, vol. 446(7138), pages 926-929, April.
    • Handle: RePEc:nat:nature:v:446:y:2007:i:7138:d:10.1038_nature05676
    DOI: 10.1038/nature05676
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    Cited by:

    1. Young Jin Kim & Tomoki Nomakuchi & Foteini Papaleonidopoulou & Lucia Yang & Qian Zhang & Adrian R. Krainer, 2022. "Gene-specific nonsense-mediated mRNA decay targeting for cystic fibrosis therapy," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Jian Han & Omer An & Xi Ren & Yangyang Song & Sze Jing Tang & Haoqing Shen & Xinyu Ke & Vanessa Hui En Ng & Daryl Jin Tai Tay & Hui Qing Tan & Dennis Kappei & Henry Yang & Leilei Chen, 2022. "Multilayered control of splicing regulatory networks by DAP3 leads to widespread alternative splicing changes in cancer," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    3. Feng Wang & Yang Xu & Robert Wang & Beatrice Zhang & Noah Smith & Amber Notaro & Samantha Gaerlan & Eric Kutschera & Kathryn E. Kadash-Edmondson & Yi Xing & Lan Lin, 2023. "TEQUILA-seq: a versatile and low-cost method for targeted long-read RNA sequencing," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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