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Two chemosensory receptors together mediate carbon dioxide detection in Drosophila

Author

Listed:
  • Walton D. Jones

    (The Rockefeller University)

  • Pelin Cayirlioglu

    (University of California)

  • Ilona Grunwald Kadow

    (University of California
    Max-Planck Institute of Neurobiology)

  • Leslie B. Vosshall

    (The Rockefeller University)

Abstract

The scent of man Many insects are equipped with neurons that detect carbon dioxide. The use to which they are put varies according to the insect's ecology: hawk-moths use it as a measure of the quality of datura flowers. Closer to home, mosquitoes and other blood-feeders are attracted to the carbon dioxide emitted by us. Drosophila too has these sensors: two receptors, called Gr21a and Gr63a, have now been identified in the fruit fly. Flies with only one of the two are insensitive to carbon dioxide, but when both genes are expressed the neurons are sensitive to the gas. Similar genes are present in the malaria mosquito, so they may be useful targets for drugs aimed at reducing the ability of mosquitoes to find humans to bite.

Suggested Citation

  • Walton D. Jones & Pelin Cayirlioglu & Ilona Grunwald Kadow & Leslie B. Vosshall, 2007. "Two chemosensory receptors together mediate carbon dioxide detection in Drosophila," Nature, Nature, vol. 445(7123), pages 86-90, January.
  • Handle: RePEc:nat:nature:v:445:y:2007:i:7123:d:10.1038_nature05466
    DOI: 10.1038/nature05466
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    Cited by:

    1. Clement Kent & Reza Azanchi & Ben Smith & Adrienne Chu & Joel Levine, 2007. "A Model-Based Analysis of Chemical and Temporal Patterns of Cuticular Hydrocarbons in Male Drosophila melanogaster," PLOS ONE, Public Library of Science, vol. 2(9), pages 1-21, September.
    2. Johnna Doherty & Amy E Sheehan & Rachel Bradshaw & A Nicole Fox & Tsai-Yi Lu & Marc R Freeman, 2014. "PI3K Signaling and Stat92E Converge to Modulate Glial Responsiveness to Axonal Injury," PLOS Biology, Public Library of Science, vol. 12(11), pages 1-16, November.

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