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Hypoxia signalling in cancer and approaches to enforce tumour regression

Author

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  • Jacques Pouysségur

    (Institute of Signalling, Developmental Biology and Cancer Research, CNRS UMR-6543, University of Nice, Centre Antoine Lacassagne)

  • Frédéric Dayan

    (Institute of Signalling, Developmental Biology and Cancer Research, CNRS UMR-6543, University of Nice, Centre Antoine Lacassagne)

  • Nathalie M. Mazure

    (Institute of Signalling, Developmental Biology and Cancer Research, CNRS UMR-6543, University of Nice, Centre Antoine Lacassagne)

Abstract

Tumour cells emerge as a result of genetic alteration of signal circuitries promoting cell growth and survival, whereas their expansion relies on nutrient supply. Oxygen limitation is central in controlling neovascularization, glucose metabolism, survival and tumour spread. This pleiotropic action is orchestrated by hypoxia-inducible factor (HIF), which is a master transcriptional factor in nutrient stress signalling. Understanding the role of HIF in intracellular pH (pHi) regulation, metabolism, cell invasion, autophagy and cell death is crucial for developing novel anticancer therapies. There are new approaches to enforce necrotic cell death and tumour regression by targeting tumour metabolism and pHi-control systems.

Suggested Citation

  • Jacques Pouysségur & Frédéric Dayan & Nathalie M. Mazure, 2006. "Hypoxia signalling in cancer and approaches to enforce tumour regression," Nature, Nature, vol. 441(7092), pages 437-443, May.
    • Handle: RePEc:nat:nature:v:441:y:2006:i:7092:d:10.1038_nature04871
    DOI: 10.1038/nature04871
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    Cited by:

    1. Nagarekha Pasupuleti & Anthony Valenzuela & Yamini Manohar & Sundeep Dugar & Jann Sarkaria, 2018. "Intracellular Urokinase uPA-PAI-1 Complex: Disruption by Small Molecule Targets Hypoxically Programmed Glioma Cells," Open Access Journal of Neurology & Neurosurgery, Juniper Publishers Inc., vol. 7(3), pages 42-59, March.

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