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A colonization factor links Vibrio cholerae environmental survival and human infection

Author

Listed:
  • Thomas J. Kirn

    (Dartmouth Medical School
    Hospital of the University of Pennsylvania)

  • Brooke A. Jude

    (Dartmouth Medical School)

  • Ronald K. Taylor

    (Dartmouth Medical School)

Abstract

Survival tricks of a pathogen Vibrio cholerae occupies two contrasting niches: the human small bowel and the aquatic ecosystem. A single protein that enhances survival in both these environments has now been identified — a colonization factor mediating attachment to both zooplankton and epithelial cells by binding to sugars on both surfaces. Considering the broad role for this protein, it may be a promising target for vaccine design.

Suggested Citation

  • Thomas J. Kirn & Brooke A. Jude & Ronald K. Taylor, 2005. "A colonization factor links Vibrio cholerae environmental survival and human infection," Nature, Nature, vol. 438(7069), pages 863-866, December.
    • Handle: RePEc:nat:nature:v:438:y:2005:i:7069:d:10.1038_nature04249
    DOI: 10.1038/nature04249
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    Cited by:

    1. Xin Huang & Thomas Nero & Ranjuna Weerasekera & Katherine H. Matej & Alex Hinbest & Zhaowei Jiang & Rebecca F. Lee & Longjun Wu & Cecilia Chak & Japinder Nijjer & Isabella Gibaldi & Hang Yang & Nathan, 2023. "Vibrio cholerae biofilms use modular adhesins with glycan-targeting and nonspecific surface binding domains for colonization," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Gareth J Williams & Greta S Aeby & Rebecca O M Cowie & Simon K Davy, 2010. "Predictive Modeling of Coral Disease Distribution within a Reef System," PLOS ONE, Public Library of Science, vol. 5(2), pages 1-10, February.

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