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A role for lateral hypothalamic orexin neurons in reward seeking

Author

Listed:
  • Glenda C. Harris

    (University of Pennsylvania)

  • Mathieu Wimmer

    (University of Pennsylvania)

  • Gary Aston-Jones

    (University of Pennsylvania)

Abstract

Food and drug craving The activation of neurons in the lateral hypothalamus of the brain that contain the novel neuropeptide orexin may be responsible for the cravings experienced by both overeaters and drug addicts. A study in rats shows that these orexin neurons are strongly stimulated in proportion to the degree of food- or drug-seeking that animals exhibit in a conditioning experiment. Direct stimulation of these orexin neurons causes a relapse of drug-seeking behaviour, and a similar relapse was induced by direct administration of orexin into a major reward centre in the brain, the ventral tegmental area. These findings reveal some of the mechanisms of motivation and reward in the brain, and have implications for understanding and treating drug addiction and overeating.

Suggested Citation

  • Glenda C. Harris & Mathieu Wimmer & Gary Aston-Jones, 2005. "A role for lateral hypothalamic orexin neurons in reward seeking," Nature, Nature, vol. 437(7058), pages 556-559, September.
    • Handle: RePEc:nat:nature:v:437:y:2005:i:7058:d:10.1038_nature04071
    DOI: 10.1038/nature04071
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    Cited by:

    1. Joram D Mul & Susanne E la Fleur & Pim W Toonen & Anthonieke Afrasiab-Middelman & Rob Binnekade & Dustin Schetters & Michel M M Verheij & Robert M Sears & Judith R Homberg & Anton N M Schoffelmeer & R, 2011. "Chronic Loss of Melanin-Concentrating Hormone Affects Motivational Aspects of Feeding in the Rat," PLOS ONE, Public Library of Science, vol. 6(5), pages 1-13, May.
    2. Robyn Mary Brown & Jennifer Lynn Short & Andrew John Lawrence, 2010. "Identification of Brain Nuclei Implicated in Cocaine-Primed Reinstatement of Conditioned Place Preference: A Behaviour Dissociable from Sensitization," PLOS ONE, Public Library of Science, vol. 5(12), pages 1-13, December.
    3. Ines Villano & Marco La Marra & Girolamo Di Maio & Vincenzo Monda & Sergio Chieffi & Ezia Guatteo & Giovanni Messina & Fiorenzo Moscatelli & Marcellino Monda & Antonietta Messina, 2022. "Physiological Role of Orexinergic System for Health," IJERPH, MDPI, vol. 19(14), pages 1-18, July.
    4. Atsushi Noritake & Taihei Ninomiya & Kenta Kobayashi & Masaki Isoda, 2023. "Chemogenetic dissection of a prefrontal-hypothalamic circuit for socially subjective reward valuation in macaques," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    5. Huan Sheng & Chao Lei & Yu Yuan & Yali Fu & Dongyang Cui & Li Yang & Da Shao & Zixuan Cao & Hao Yang & Xinli Guo & Chenshan Chu & Yaxian Wen & Zhangyin Cai & Ming Chen & Bin Lai & Ping Zheng, 2023. "Nucleus accumbens circuit disinhibits lateral hypothalamus glutamatergic neurons contributing to morphine withdrawal memory in male mice," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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