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Nonlinear elasticity in biological gels

Author

Listed:
  • Cornelis Storm

    (University of Pennsylvania
    Universiteit Leiden)

  • Jennifer J. Pastore

    (University of Pennsylvania)

  • F. C. MacKintosh

    (Vrije Universiteit Amsterdam)

  • T. C. Lubensky

    (University of Pennsylvania
    University of Pennsylvania)

  • Paul A. Janmey

    (University of Pennsylvania
    University of Pennsylvania)

Abstract

Biomaterials under stress Unlike most synthetic materials, biological materials often stiffen as they are strained. This property, critical for the physiological function of tissues such as blood vessels, lung parenchyma and blood clots, has been documented since the nineteenth century, but the molecular structures and design principles responsible for it are unknown. Storm et al. now show that a much simpler theory can account for strain stiffening in a wide range of biopolymer gels formed from cytoskeletal and extracellular proteins. According to this theory, systems of semiflexible chains such as filamentous proteins arranged in an open crosslinked meshwork invariably stiffen at low strains without the need for a specific architecture or multiple elements with different intrinsic stiffnesses.

Suggested Citation

  • Cornelis Storm & Jennifer J. Pastore & F. C. MacKintosh & T. C. Lubensky & Paul A. Janmey, 2005. "Nonlinear elasticity in biological gels," Nature, Nature, vol. 435(7039), pages 191-194, May.
    • Handle: RePEc:nat:nature:v:435:y:2005:i:7039:d:10.1038_nature03521
    DOI: 10.1038/nature03521
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    Cited by:

    1. M․, Hariprasad & Venkatapathi, Murugesan, 2021. "Semi-analytical solutions for eigenvalue problems of chains and periodic graphs," Applied Mathematics and Computation, Elsevier, vol. 411(C).
    2. Qingqiao Xie & Yuandi Zhuang & Gaojun Ye & Tiankuo Wang & Yi Cao & Lingxiang Jiang, 2021. "Astral hydrogels mimic tissue mechanics by aster-aster interpenetration," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    3. Ashley L. Nord & Anaïs Biquet-Bisquert & Manouk Abkarian & Théo Pigaglio & Farida Seduk & Axel Magalon & Francesco Pedaci, 2022. "Dynamic stiffening of the flagellar hook," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    4. René F M van Oers & Elisabeth G Rens & Danielle J LaValley & Cynthia A Reinhart-King & Roeland M H Merks, 2014. "Mechanical Cell-Matrix Feedback Explains Pairwise and Collective Endothelial Cell Behavior In Vitro," PLOS Computational Biology, Public Library of Science, vol. 10(8), pages 1-14, August.
    5. Jiu-Tao Hang & Yu Kang & Guang-Kui Xu & Huajian Gao, 2021. "A hierarchical cellular structural model to unravel the universal power-law rheological behavior of living cells," Nature Communications, Nature, vol. 12(1), pages 1-7, December.
    6. Jin Qian & Huajian Gao, 2010. "Soft Matrices Suppress Cooperative Behaviors among Receptor-Ligand Bonds in Cell Adhesion," PLOS ONE, Public Library of Science, vol. 5(8), pages 1-9, August.
    7. Yang Li & Yunfeng Li & Elisabeth Prince & Jeffrey I. Weitz & Sergey Panyukov & Arun Ramachandran & Michael Rubinstein & Eugenia Kumacheva, 2022. "Fibrous hydrogels under biaxial confinement," Nature Communications, Nature, vol. 13(1), pages 1-6, December.
    8. Jason X. Liu & Mikko P. Haataja & Andrej Košmrlj & Sujit S. Datta & Craig B. Arnold & Rodney D. Priestley, 2023. "Liquid–liquid phase separation within fibrillar networks," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    9. Xin Tang & Alireza Tofangchi & Sandeep V Anand & Taher A Saif, 2014. "A Novel Cell Traction Force Microscopy to Study Multi-Cellular System," PLOS Computational Biology, Public Library of Science, vol. 10(6), pages 1-15, June.

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