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Susceptibility to leprosy is associated with PARK2 and PACRG

Author

Listed:
  • Marcelo T. Mira

    (McGill University
    Centro de Ciências Biológicas e da Saúde, Pontifícia Universidade Católica do Paraná)

  • Alexandre Alcaïs

    (Université de Paris René Descartes)

  • Nguyen Van Thuc

    (Hospital for Dermato-Venereology)

  • Milton O. Moraes

    (Leprosy Laboratory, Tropical Medicine Department Oswaldo Cruz Institute, FIOCRUZ)

  • Celestino Di Flumeri

    (McGill University)

  • Vu Hong Thai

    (Hospital for Dermato-Venereology)

  • Mai Chi Phuong

    (Hospital for Dermato-Venereology)

  • Nguyen Thu Huong

    (Hospital for Dermato-Venereology)

  • Nguyen Ngoc Ba

    (Hospital for Dermato-Venereology)

  • Pham Xuan Khoa

    (Hospital for Dermato-Venereology)

  • Euzenir N. Sarno

    (Leprosy Laboratory, Tropical Medicine Department Oswaldo Cruz Institute, FIOCRUZ)

  • Andrea Alter

    (McGill University)

  • Alexandre Montpetit

    (McGill University and Genome Québec Innovation Centre)

  • Maria E. Moraes

    (Instituto Nacional do Cancer, Ministério da Saúde)

  • José R. Moraes

    (Instituto Nacional do Cancer, Ministério da Saúde)

  • Carole Doré

    (McGill University and Genome Québec Innovation Centre)

  • Caroline J. Gallant

    (McGill University)

  • Pierre Lepage

    (McGill University and Genome Québec Innovation Centre)

  • Andrei Verner

    (McGill University and Genome Québec Innovation Centre)

  • Esther van de Vosse

    (Leiden University Medical Center)

  • Thomas J. Hudson

    (McGill University
    McGill University and Genome Québec Innovation Centre)

  • Laurent Abel

    (Université de Paris René Descartes)

  • Erwin Schurr

    (McGill University)

Abstract

Leprosy is caused by Mycobacterium leprae and affects about 700,000 individuals each year1. It has long been thought that leprosy has a strong genetic component2, and recently we mapped a leprosy susceptibility locus to chromosome 6 region q25–q26 (ref. 3). Here we investigate this region further by using a systematic association scan of the chromosomal interval most likely to harbour this leprosy susceptibility locus. In 197 Vietnamese families we found a significant association between leprosy and 17 markers located in a block of approx. 80 kilobases overlapping the 5′ regulatory region shared by the Parkinson's disease gene PARK2 and the co-regulated gene PACRG. Possession of as few as two of the 17 risk alleles was highly predictive of leprosy. This was confirmed in a sample of 975 unrelated leprosy cases and controls from Brazil in whom the same alleles were strongly associated with leprosy. Variants in the regulatory region shared by PARK2 and PACRG therefore act as common risk factors for leprosy.

Suggested Citation

  • Marcelo T. Mira & Alexandre Alcaïs & Nguyen Van Thuc & Milton O. Moraes & Celestino Di Flumeri & Vu Hong Thai & Mai Chi Phuong & Nguyen Thu Huong & Nguyen Ngoc Ba & Pham Xuan Khoa & Euzenir N. Sarno &, 2004. "Susceptibility to leprosy is associated with PARK2 and PACRG," Nature, Nature, vol. 427(6975), pages 636-640, February.
    • Handle: RePEc:nat:nature:v:427:y:2004:i:6975:d:10.1038_nature02326
    DOI: 10.1038/nature02326
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    Cited by:

    1. Niyi Awofeso, 2011. "Leprosy: International Public Health Policies and Public Health Eras," Administrative Sciences, MDPI, vol. 1(1), pages 1-13, September.

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