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A gene expression atlas of the central nervous system based on bacterial artificial chromosomes

Author

Listed:
  • Shiaoching Gong

    (Howard Hughes Medical Institute, The Rockefeller University)

  • Chen Zheng

    (Howard Hughes Medical Institute, The Rockefeller University)

  • Martin L. Doughty

    (Howard Hughes Medical Institute, The Rockefeller University)

  • Kasia Losos

    (Howard Hughes Medical Institute, The Rockefeller University)

  • Nicholas Didkovsky

    (The Rockefeller University)

  • Uta B. Schambra

    (East Tennessee State University)

  • Norma J. Nowak

    (Roswell Park Cancer Institute)

  • Alexandra Joyner

    (New York University School of Medicine and Howard Hughes Medical Institute)

  • Gabrielle Leblanc

    (National Institute of Neurological Disorders and Stroke, NIH)

  • Mary E. Hatten

    (The Rockefeller University)

  • Nathaniel Heintz

    (Howard Hughes Medical Institute, The Rockefeller University)

Abstract

The mammalian central nervous system (CNS) contains a remarkable array of neural cells, each with a complex pattern of connections that together generate perceptions and higher brain functions. Here we describe a large-scale screen to create an atlas of CNS gene expression at the cellular level, and to provide a library of verified bacterial artificial chromosome (BAC) vectors and transgenic mouse lines that offer experimental access to CNS regions, cell classes and pathways. We illustrate the use of this atlas to derive novel insights into gene function in neural cells, and into principal steps of CNS development. The atlas, library of BAC vectors and BAC transgenic mice generated in this screen provide a rich resource that allows a broad array of investigations not previously available to the neuroscience community.

Suggested Citation

  • Shiaoching Gong & Chen Zheng & Martin L. Doughty & Kasia Losos & Nicholas Didkovsky & Uta B. Schambra & Norma J. Nowak & Alexandra Joyner & Gabrielle Leblanc & Mary E. Hatten & Nathaniel Heintz, 2003. "A gene expression atlas of the central nervous system based on bacterial artificial chromosomes," Nature, Nature, vol. 425(6961), pages 917-925, October.
    • Handle: RePEc:nat:nature:v:425:y:2003:i:6961:d:10.1038_nature02033
    DOI: 10.1038/nature02033
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