IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v422y2003i6929d10.1038_nature01458.html
   My bibliography  Save this article

Links between signal transduction, transcription and adhesion in epithelial bud development

Author

Listed:
  • Colin Jamora

    (The Rockefeller University)

  • Ramanuj DasGupta

    (The Rockefeller University
    Howard Hughes Medical Institute, Harvard Medical School)

  • Pawel Kocieniewski

    (The Rockefeller University)

  • Elaine Fuchs

    (The Rockefeller University)

Abstract

The morphogenesis of organs as diverse as lungs, teeth and hair follicles is initiated by a downgrowth from a layer of epithelial stem cells1,2. During follicular morphogenesis, stem cells form this bud structure by changing their polarity and cell–cell contacts. Here we show that this process is achieved through simultaneous receipt of two external signals: a Wnt protein to stabilize β-catenin, and a bone morphogenetic protein (BMP) inhibitor to produce Lef1. β-Catenin then binds to, and activates, Lef1 transcription complexes that appear to act uncharacteristically by downregulating the gene encoding E-cadherin, an important component of polarity and intercellular adhesion. When either signal is missing, functional Lef1 complexes are not made, and E-cadherin downregulation and follicle morphogenesis are impaired. In Drosophila, E-cadherin can influence the plane of cell division and cytoskeletal dynamics3. Consistent with this notion, we show that forced elevation of E-cadherin levels block invagination and follicle production. Our findings reveal an intricate molecular programme that links two extracellular signalling pathways to the formation of a nuclear transcription factor that acts on target genes to remodel cellular junctions and permit follicle formation.

Suggested Citation

  • Colin Jamora & Ramanuj DasGupta & Pawel Kocieniewski & Elaine Fuchs, 2003. "Links between signal transduction, transcription and adhesion in epithelial bud development," Nature, Nature, vol. 422(6929), pages 317-322, March.
    • Handle: RePEc:nat:nature:v:422:y:2003:i:6929:d:10.1038_nature01458
    DOI: 10.1038/nature01458
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature01458
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature01458?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Valeria Sibilia & Daniele Bottai & Roberto Maggi & Francesca Pagani & Raffaella Chiaramonte & Domenica Giannandrea & Valentina Citro & Natalia Platonova & Lavinia Casati, 2021. "Sex Steroid Regulation of Oxidative Stress in Bone Cells: An In Vitro Study," IJERPH, MDPI, vol. 18(22), pages 1-23, November.
    2. Cummings, F.W, 2004. "A model of morphogenesis," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 339(3), pages 531-547.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:422:y:2003:i:6929:d:10.1038_nature01458. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.