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The digital code of DNA

Author

Listed:
  • Leroy Hood

    (Institute for Systems Biology)

  • David Galas

    (Keck Graduate Institute of Applied Sciences)

Abstract

The discovery of the structure of DNA transformed biology profoundly, catalysing the sequencing of the human genome and engendering a new view of biology as an information science. Two features of DNA structure account for much of its remarkable impact on science: its digital nature and its complementarity, whereby one strand of the helix binds perfectly with its partner. DNA has two types of digital information — the genes that encode proteins, which are the molecular machines of life, and the gene regulatory networks that specify the behaviour of the genes.

Suggested Citation

  • Leroy Hood & David Galas, 2003. "The digital code of DNA," Nature, Nature, vol. 421(6921), pages 444-448, January.
    • Handle: RePEc:nat:nature:v:421:y:2003:i:6921:d:10.1038_nature01410
    DOI: 10.1038/nature01410
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    Cited by:

    1. Luca Marchetti & Rosario Lombardo & Corrado Priami, 2017. "HSimulator: Hybrid Stochastic/Deterministic Simulation of Biochemical Reaction Networks," Complexity, Hindawi, vol. 2017, pages 1-12, December.
    2. Dana Cohen, 2022. "General Designs Reveal a Purine-Pyrimidine Structural Code in Human DNA," Mathematics, MDPI, vol. 10(15), pages 1-20, August.
    3. Dan Frumkin & Adam Wasserstrom & Shai Kaplan & Uriel Feige & Ehud Shapiro, 2005. "Genomic Variability within an Organism Exposes Its Cell Lineage Tree," PLOS Computational Biology, Public Library of Science, vol. 1(5), pages 1-13, October.

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