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Ten years of tension: single-molecule DNA mechanics

Author

Listed:
  • Carlos Bustamante

    (University of California
    University of California)

  • Zev Bryant

    (University of California)

  • Steven B. Smith

    (University of California)

Abstract

The basic features of DNA were elucidated during the half-century following the discovery of the double helix. But it is only during the past decade that researchers have been able to manipulate single molecules of DNA to make direct measurements of its mechanical properties. These studies have illuminated the nature of interactions between DNA and proteins, the constraints within which the cellular machinery operates, and the forces created by DNA-dependent motors.

Suggested Citation

  • Carlos Bustamante & Zev Bryant & Steven B. Smith, 2003. "Ten years of tension: single-molecule DNA mechanics," Nature, Nature, vol. 421(6921), pages 423-427, January.
    • Handle: RePEc:nat:nature:v:421:y:2003:i:6921:d:10.1038_nature01405
    DOI: 10.1038/nature01405
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    Cited by:

    1. Li Liu & Ying Fang & Qingsheng Huang & Jianhua Wu, 2011. "A Rigidity-Enhanced Antimicrobial Activity: A Case for Linear Cationic α-Helical Peptide HP(2–20) and Its Four Analogues," PLOS ONE, Public Library of Science, vol. 6(1), pages 1-8, January.
    2. Young-Joo Kim & Do-Nyun Kim, 2016. "Structural Basis for Elastic Mechanical Properties of the DNA Double Helix," PLOS ONE, Public Library of Science, vol. 11(4), pages 1-11, April.
    3. Sangram Kadam & Kiran Kumari & Vinoth Manivannan & Shuvadip Dutta & Mithun K. Mitra & Ranjith Padinhateeri, 2023. "Predicting scale-dependent chromatin polymer properties from systematic coarse-graining," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    4. Korbinian Liebl & Martin Zacharias, 2020. "How global DNA unwinding causes non-uniform stress distribution and melting of DNA," PLOS ONE, Public Library of Science, vol. 15(5), pages 1-21, May.
    5. Fang-Chieh Chou & Jan Lipfert & Rhiju Das, 2014. "Blind Predictions of DNA and RNA Tweezers Experiments with Force and Torque," PLOS Computational Biology, Public Library of Science, vol. 10(8), pages 1-19, August.

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