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A re-examination of proximodistal patterning during vertebrate limb development

Author

Listed:
  • Andrew T. Dudley

    (Harvard Medical School)

  • María A. Ros

    (Universidad de Cantabria)

  • Clifford J. Tabin

    (Harvard Medical School)

Abstract

The ‘progress zone’ model provides a framework for understanding progressive development of the vertebrate limb1. This model holds that undifferentiated cells in a zone of fixed size at the distal tip of the limb bud (the progress zone) undergo a progressive change in positional information such that their specification is altered from more proximal to more distal fates. This positional change is thought to be driven by an internal clock that is kept active as long as the cells remain in the progress zone. However, owing to cell division, the most proximal of these cells are continually pushed outside the confines of the zone. As they exit, clock function ceases and cells become fixed with the positional value last attained while within the zone. In contrast to this model, our data suggest that the various limb segments are ‘specified’ early in limb development as distinct domains, with subsequent development involving expansion of these progenitor populations before differentiation. We also find, however, that the distal limb mesenchyme becomes progressively ‘determined’, that is, irreversibly fixed, to a progressively limited range of potential proximodistal fates.

Suggested Citation

  • Andrew T. Dudley & María A. Ros & Clifford J. Tabin, 2002. "A re-examination of proximodistal patterning during vertebrate limb development," Nature, Nature, vol. 418(6897), pages 539-544, August.
    • Handle: RePEc:nat:nature:v:418:y:2002:i:6897:d:10.1038_nature00945
    DOI: 10.1038/nature00945
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    Cited by:

    1. Zeng, Wei & Thomas, Gilberto L & Glazier, James A, 2004. "Non-Turing stripes and spots: a novel mechanism for biological cell clustering," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 341(C), pages 482-494.
    2. Bernd Boehm & Henrik Westerberg & Gaja Lesnicar-Pucko & Sahdia Raja & Michael Rautschka & James Cotterell & Jim Swoger & James Sharpe, 2010. "The Role of Spatially Controlled Cell Proliferation in Limb Bud Morphogenesis," PLOS Biology, Public Library of Science, vol. 8(7), pages 1-21, July.
    3. Sofia Sedas Perez & Caitlin McQueen & Holly Stainton & Joseph Pickering & Kavitha Chinnaiya & Patricia Saiz-Lopez & Marysia Placzek & Maria A. Ros & Matthew Towers, 2023. "Fgf signalling triggers an intrinsic mesodermal timer that determines the duration of limb patterning," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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