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Morphogen gradient interpretation

Author

Listed:
  • J. B. Gurdon

    (Wellcome/CRC Institute
    University of Cambridge)

  • P.-Y. Bourillot

    (Wellcome/CRC Institute
    University of Cambridge)

Abstract

A morphogen gradient is an important concept in developmental biology, because it describes a mechanism by which the emission of a signal from one part of an embryo can determine the location, differentiation and fate of many surrounding cells. The value of this idea has been clear for over half a century, but only recently have experimental systems and methods of analysis progressed to the point where we begin to understand how a cell can sense and respond to tiny changes in minute concentrations of extracellular signalling factors.

Suggested Citation

  • J. B. Gurdon & P.-Y. Bourillot, 2001. "Morphogen gradient interpretation," Nature, Nature, vol. 413(6858), pages 797-803, October.
    • Handle: RePEc:nat:nature:v:413:y:2001:i:6858:d:10.1038_35101500
    DOI: 10.1038/35101500
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    Cited by:

    1. Grant Ongo & Sébastien G Ricoult & Timothy E Kennedy & David Juncker, 2014. "Ordered, Random, Monotonic and Non-Monotonic Digital Nanodot Gradients," PLOS ONE, Public Library of Science, vol. 9(9), pages 1-11, September.
    2. Yudai Hatakeyama & Nen Saito & Yusuke Mii & Ritsuko Takada & Takuma Shinozuka & Tatsuya Takemoto & Honda Naoki & Shinji Takada, 2023. "Intercellular exchange of Wnt ligands reduces cell population heterogeneity during embryogenesis," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. Benjamin L. Walker & Qing Nie, 2023. "NeST: nested hierarchical structure identification in spatial transcriptomic data," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    4. Cummings, F.W, 2004. "A model of morphogenesis," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 339(3), pages 531-547.

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