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Stochastic sensors inspired by biology

Author

Listed:
  • Hagan Bayley

    (The Texas A&M University System Health Science Center
    Texas A&M University
    Center for Integrated Microchemical Systems, Texas A&M University)

  • Paul S. Cremer

    (Texas A&M University
    Center for Integrated Microchemical Systems, Texas A&M University)

Abstract

Sensory systems use a variety of membrane-bound receptors, including responsive ion channels, to discriminate between a multitude of stimuli. Here we describe how engineered membrane pores can be used to make rapid and sensitive biosensors with potential applications that range from the detection of biological warfare agents to pharmaceutical screening. Notably, use of the engineered pores in stochastic sensing, a single-molecule detection technology, reveals the identity of an analyte as well as its concentration.

Suggested Citation

  • Hagan Bayley & Paul S. Cremer, 2001. "Stochastic sensors inspired by biology," Nature, Nature, vol. 413(6852), pages 226-230, September.
  • Handle: RePEc:nat:nature:v:413:y:2001:i:6852:d:10.1038_35093038
    DOI: 10.1038/35093038
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    Cited by:

    1. Weichao Peng & Shuaihu Yan & Ke Zhou & Hai-Chen Wu & Lei Liu & Yuliang Zhao, 2023. "High-resolution discrimination of homologous and isomeric proteinogenic amino acids in nanopore sensors with ultrashort single-walled carbon nanotubes," Nature Communications, Nature, vol. 14(1), pages 1-8, December.

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