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The Hedgehog and Wnt signalling pathways in cancer

Author

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  • Jussi Taipale

    (Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine)

  • Philip A. Beachy

    (Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine)

Abstract

The Wnt and Hedgehog (Hh) signalling pathways have long been known to direct growth and patterning during embryonic development. Recent evidence also implicates these pathways in the postembryonic regulation of stem-cell number in epithelia such as those of the skin and intestine, which undergo constant renewal. A pathological role for the Wnt and Hh pathways has emerged from studies showing a high frequency of specific human cancers associated with mutations that constitutively activate the transcriptional response of these pathways. This article focuses on Hh and Wnt signal transduction and reviews evidence suggesting that tumorigenesis associated with pathway activation may result from mis-specification of cells towards stem-cell or stem cell-like fates.

Suggested Citation

  • Jussi Taipale & Philip A. Beachy, 2001. "The Hedgehog and Wnt signalling pathways in cancer," Nature, Nature, vol. 411(6835), pages 349-354, May.
    • Handle: RePEc:nat:nature:v:411:y:2001:i:6835:d:10.1038_35077219
    DOI: 10.1038/35077219
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    Cited by:

    1. Indra Adrianto & Chee Paul Lin & Jessica J Hale & Albert M Levin & Indrani Datta & Ryan Parker & Adam Adler & Jennifer A Kelly & Kenneth M Kaufman & Christopher J Lessard & Kathy L Moser & Robert P Ki, 2012. "Genome-Wide Association Study of African and European Americans Implicates Multiple Shared and Ethnic Specific Loci in Sarcoidosis Susceptibility," PLOS ONE, Public Library of Science, vol. 7(8), pages 1-10, August.
    2. Felicite K. Noubissi & Clement G. Yedjou & Vladimir S. Spiegelman & Paul B. Tchounwou, 2018. "Cross-Talk between Wnt and Hh Signaling Pathways in the Pathology of Basal Cell Carcinoma," IJERPH, MDPI, vol. 15(7), pages 1-13, July.
    3. Cummings, F.W, 2004. "A model of morphogenesis," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 339(3), pages 531-547.
    4. Joachim Hanna & Flavio Beke & Louise M. O’Brien & Chrysa Kapeni & Hung-Chang Chen & Valentina Carbonaro & Alexander B. Kim & Kamal Kishore & Timon E. Adolph & Mikkel-Ole Skjoedt & Karsten Skjoedt & Ma, 2022. "Cell-autonomous Hedgehog signaling controls Th17 polarization and pathogenicity," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    5. Gaetane Nocturne & Stephan Pavy & Saida Boudaoud & Raphaèle Seror & Philippe Goupille & Philippe Chanson & Désirée van der Heijde & Floris van Gaalen & Francis Berenbaum & Xavier Mariette & Karine Bri, 2015. "Increase in Dickkopf-1 Serum Level in Recent Spondyloarthritis. Data from the DESIR Cohort," PLOS ONE, Public Library of Science, vol. 10(8), pages 1-16, August.

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