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Toll-like receptors in the induction of the innate immune response

Author

Listed:
  • Alan Aderem

    (University of Washington)

  • Richard J. Ulevitch

    (The Scripps Research Institute)

Abstract

The innate immune response is the first line of defence against infectious disease. The principal challenge for the host is to detect the pathogen and mount a rapid defensive response. A group of proteins that comprise the Toll or Toll-like family of receptors perform this role in vertebrate and invertebrate organisms. This reflects a remarkable conservation of function and it is therefore not surprising that studies of the mechanism by which they act has revealed new and important insights into host defence.

Suggested Citation

  • Alan Aderem & Richard J. Ulevitch, 2000. "Toll-like receptors in the induction of the innate immune response," Nature, Nature, vol. 406(6797), pages 782-787, August.
    • Handle: RePEc:nat:nature:v:406:y:2000:i:6797:d:10.1038_35021228
    DOI: 10.1038/35021228
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    Cited by:

    1. Yueyue Gui & Yujing Zeng & Binrui Chen & Yueping Yang & Jiehua Ma & Chao Li, 2023. "A smart pathogen detector engineered from intracellular hydrogelation of DNA-decorated macrophages," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Longbiao Zhu & Hua Yuan & Tao Jiang & Ruixia Wang & Hongxia Ma & Shuangyue Zhang, 2013. "Association of TLR2 and TLR4 Polymorphisms with Risk of Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-9, December.
    3. Yang Cheng & Yun Zhu & Xiuping Huang & Wei Zhang & Zelong Han & Side Liu, 2015. "Association between TLR2 and TLR4 Gene Polymorphisms and the Susceptibility to Inflammatory Bowel Disease: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(5), pages 1-20, May.
    4. Genetha Gray & Pamela Williams & W. Brown & Jean-Loup Faulon & Kenneth Sale, 2010. "Disparate data fusion for protein phosphorylation prediction," Annals of Operations Research, Springer, vol. 174(1), pages 219-235, February.

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