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The temporal requirement for endothelin receptor-B signalling during neural crest development

Author

Listed:
  • Myung K. Shin

    (Howard Hughes Medical Institute and Department of Molecular Biology Princeton University)

  • John M. Levorse

    (Howard Hughes Medical Institute and Department of Molecular Biology Princeton University)

  • Robert S. Ingram

    (Howard Hughes Medical Institute and Department of Molecular Biology Princeton University)

  • Shirley M. Tilghman

    (Howard Hughes Medical Institute and Department of Molecular Biology Princeton University)

Abstract

Endothelin receptor B (EDNRB) is a G-protein-coupled receptor with seven transmembrane domains which is required for the development of melanocytes and enteric neurons. Mice that are homozygous for a null mutation in the Ednrb gene are almost completely white and die as juveniles from megacolon. To determine when EDNRB signalling is required during embryogenesis, we have exploited the tetracycline-inducible system to generate strains of mice in which the endogenous Ednrb locus is under the control of the tetracycline-dependant transactivators tTa or rtTA. By using this system to express Ednrb at different stages of embryogenesis, we have determined that EDNRB is required during a restricted period of neural crest development between embryonic days 10 and 12.5. Moreover, our results imply that EDNRB is required for the migration of both melanoblasts and enteric neuroblasts.

Suggested Citation

  • Myung K. Shin & John M. Levorse & Robert S. Ingram & Shirley M. Tilghman, 1999. "The temporal requirement for endothelin receptor-B signalling during neural crest development," Nature, Nature, vol. 402(6761), pages 496-501, December.
    • Handle: RePEc:nat:nature:v:402:y:1999:i:6761:d:10.1038_990040
    DOI: 10.1038/990040
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    Cited by:

    1. Shu Wu & Majed Alharthi & Weihua Yin & Qaiser Abbas & Adnan Noor Shah & Saeed ur Rahman & Jamal Khan, 2021. "The Carbon-Neutral Energy Consumption and Emission Volatility: The Causality Analysis of ASEAN Region," Energies, MDPI, vol. 14(10), pages 1-14, May.

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