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The global record of memory in hippocampal neuronal activity

Author

Listed:
  • Emma R. Wood

    (Laboratory of Cognitive Neurobiology, Boston University)

  • Paul A. Dudchenko

    (Laboratory of Cognitive Neurobiology, Boston University)

  • Howard Eichenbaum

    (Laboratory of Cognitive Neurobiology, Boston University)

Abstract

In humans the hippocampal region of the brain is crucial for declarative1 or episodic2 memory for a broad range of materials. In contrast, there has been controversy over whether the hippocampus mediates a similarly general memory function in other species, or whether it is dedicated to spatial memory processing3,4,5,6. Evidence for the spatial view is derived principally from the observations of ‘place cells’—hippocampal neurons that fire whenever the animal is in a particular location in its environment7,8, or when it perceives a specific stimulus or performs a specific behaviour in a particular place3,4. We trained rats to perform the same recognition memory task in several distinct locations in a rich spatial environment and found that the activity of many hippocampal neurons was related consistently to perceptual, behavioural or cognitive events, regardless of the location where these events occurred. These results indicate that non-spatial events are fundamental elements of hippocampal representation, and support the view that, across species, the hippocampus has a broad role in information processing associated with memory.

Suggested Citation

  • Emma R. Wood & Paul A. Dudchenko & Howard Eichenbaum, 1999. "The global record of memory in hippocampal neuronal activity," Nature, Nature, vol. 397(6720), pages 613-616, February.
  • Handle: RePEc:nat:nature:v:397:y:1999:i:6720:d:10.1038_17605
    DOI: 10.1038/17605
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    Cited by:

    1. Maryam Najafian Jazi & Adrian Tymorek & Ting-Yun Yen & Felix Jose Kavarayil & Moritz Stingl & Sherman Richard Chau & Benay Baskurt & Celia García Vilela & Kevin Allen, 2023. "Hippocampal firing fields anchored to a moving object predict homing direction during path-integration-based behavior," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    2. Yi-Fan Zeng & Ke-Xin Yang & Yilong Cui & Xiao-Na Zhu & Rui Li & Hanqing Zhang & Dong Chuan Wu & Raymond C. Stevens & Ji Hu & Ning Zhou, 2024. "Conjunctive encoding of exploratory intentions and spatial information in the hippocampus," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    3. Carina Curto & Vladimir Itskov, 2008. "Cell Groups Reveal Structure of Stimulus Space," PLOS Computational Biology, Public Library of Science, vol. 4(10), pages 1-13, October.
    4. Diego B. Piza & Benjamin W. Corrigan & Roberto A. Gulli & Sonia Carmo & A. Claudio Cuello & Lyle Muller & Julio Martinez-Trujillo, 2024. "Primacy of vision shapes behavioral strategies and neural substrates of spatial navigation in marmoset hippocampus," Nature Communications, Nature, vol. 15(1), pages 1-21, December.

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