IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v392y1998i6673d10.1038_32588.html
   My bibliography  Save this article

Dendritic cells and the control of immunity

Author

Listed:
  • Jacques Banchereau

    (Baylor Institute for Immunology, Research, Baylor Research Institute
    Laboratory of Cellular Physiology and Immunology, Rockefeller University)

  • Ralph M. Steinman

    (Baylor Institute for Immunology, Research, Baylor Research Institute
    Laboratory of Cellular Physiology and Immunology, Rockefeller University)

Abstract

B and T lymphocytes are the mediators of immunity, but their function is under the control of dendritic cells. Dendritic cells in the periphery capture and process antigens, express lymphocyte co-stimulatory molecules, migrate to lymphoid organs and secrete cytokines to initiate immune responses. They not only activate lymphocytes, they also tolerize T cells to antigens that are innate to the body (self-antigens), thereby minimizing autoimmune reactions. Once a neglected cell type, dendritic cells can now be readily obtained in sufficient quantities to allow molecular and cell biological analysis. With knowledge comes the realization that these cells are a powerful tool for manipulating the immune system.

Suggested Citation

  • Jacques Banchereau & Ralph M. Steinman, 1998. "Dendritic cells and the control of immunity," Nature, Nature, vol. 392(6673), pages 245-252, March.
    • Handle: RePEc:nat:nature:v:392:y:1998:i:6673:d:10.1038_32588
    DOI: 10.1038/32588
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/32588
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/32588?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Dominic Henn & Dehua Zhao & Dharshan Sivaraj & Artem Trotsyuk & Clark Andrew Bonham & Katharina S. Fischer & Tim Kehl & Tobias Fehlmann & Autumn H. Greco & Hudson C. Kussie & Sylvia E. Moortgat Illouz, 2023. "Cas9-mediated knockout of Ndrg2 enhances the regenerative potential of dendritic cells for wound healing," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Thanh Loc Nguyen & Youngjin Choi & Jihye Im & Hyunsu Shin & Ngoc Man Phan & Min Kyung Kim & Seung Woo Choi & Jaeyun Kim, 2022. "Immunosuppressive biomaterial-based therapeutic vaccine to treat multiple sclerosis via re-establishing immune tolerance," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Yael Korem & Pablo Szekely & Yuval Hart & Hila Sheftel & Jean Hausser & Avi Mayo & Michael E Rothenberg & Tomer Kalisky & Uri Alon, 2015. "Geometry of the Gene Expression Space of Individual Cells," PLOS Computational Biology, Public Library of Science, vol. 11(7), pages 1-27, July.
    4. Kulvinder Kochar Kaur & Gautam Allahbadia & Mandeep Singh, 2016. "Advances in the Therapy of Advanced Ovarian Cancer-Special Emphasis on the PD1/PDL1 Pathway," Current Trends in Biomedical Engineering & Biosciences, Juniper Publishers Inc., vol. 1(2), pages 32-40, December.
    5. Bangyuan Wu & Hengmin Cui & Xi Peng & Jing Fang & Zhicai Zuo & Junliang Deng & Jianying Huang, 2014. "Analysis of the Toll-Like Receptor 2-2 (TLR2-2) and TLR4 mRNA Expression in the Intestinal Mucosal Immunity of Broilers Fed on Diets Supplemented with Nickel Chloride," IJERPH, MDPI, vol. 11(1), pages 1-14, January.
    6. Iraj Hosseini & Lucio Gama & Feilim Mac Gabhann, 2015. "Multiplexed Component Analysis to Identify Genes Contributing to the Immune Response during Acute SIV Infection," PLOS ONE, Public Library of Science, vol. 10(5), pages 1-28, May.
    7. Kalijn F. Bol & Gerty Schreibelt & Martine Bloemendal & Wouter W. Willigen & Simone Hins-de Bree & Anna L. Goede & Annemiek J. Boer & Kevin J. H. Bos & Tjitske Duiveman-de Boer & Michel A. M. Olde Nor, 2024. "Adjuvant dendritic cell therapy in stage IIIB/C melanoma: the MIND-DC randomized phase III trial," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    8. Sahil Inamdar & Abhirami P. Suresh & Joslyn L. Mangal & Nathan D. Ng & Alison Sundem & Christopher Wu & Kelly Lintecum & Abhirami Thumsi & Taravat Khodaei & Michelle Halim & Nicole Appel & Madhan Moha, 2023. "Rescue of dendritic cells from glycolysis inhibition improves cancer immunotherapy in mice," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    9. Caroline Hoffmann & Floriane Noel & Maximilien Grandclaudon & Lucile Massenet-Regad & Paula Michea & Philemon Sirven & Lilith Faucheux & Aurore Surun & Olivier Lantz & Mylene Bohec & Jian Ye & Weihua , 2022. "PD-L1 and ICOSL discriminate human Secretory and Helper dendritic cells in cancer, allergy and autoimmunity," Nature Communications, Nature, vol. 13(1), pages 1-20, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:392:y:1998:i:6673:d:10.1038_32588. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.