Author
Listed:
- Tzu-Ting Chen
(National Health Research Institutes)
- Jaeyoung Kim
(Samsung Medical Center
Seoul National University Bundang Hospital)
- Max Lam
(Massachusetts General Hospital
Harvard Medical School
Genome Institute of Singapore
Northwell Health)
- Yi-Fang Chuang
(National Yang Ming Chiao Tung University)
- Yen-Ling Chiu
(Yuan Ze University
Far Eastern Memorial Hospital)
- Shu-Chin Lin
(National Health Research Institutes)
- Sang-Hyuk Jung
(University of Pennsylvania)
- Beomsu Kim
(Samsung Medical Center)
- Soyeon Kim
(Massachusetts General Hospital
the Broad Institute of MIT and Harvard)
- Chamlee Cho
(Samsung Medical Center)
- Injeong Shim
(Samsung Medical Center)
- Sanghyeon Park
(Samsung Medical Center)
- Yeeun Ahn
(Samsung Medical Center)
- Aysu Okbay
(Vrije Universiteit Amsterdam)
- Hyemin Jang
(Sungkyunkwan University School of Medicine
Samsung Medical Center)
- Hee Jin Kim
(Sungkyunkwan University School of Medicine
Samsung Medical Center)
- Sang Won Seo
(Sungkyunkwan University School of Medicine
Samsung Medical Center)
- Woong-Yang Park
(Sungkyunkwan University School of Medicine)
- Tian Ge
(the Broad Institute of MIT and Harvard
Massachusetts General Hospital
Harvard Medical School)
- Hailiang Huang
(Massachusetts General Hospital
Harvard Medical School
the Broad Institute of MIT and Harvard)
- Yen-Chen Anne Feng
(National Taiwan University
National Taiwan University)
- Yen-Feng Lin
(National Health Research Institutes
National Yang Ming Chiao Tung University
National Cheng Kung University)
- Woojae Myung
(Seoul National University Bundang Hospital
Seoul National University College of Medicine)
- Chia-Yen Chen
(Biogen)
- Hong-Hee Won
(Samsung Medical Center
Sungkyunkwan University School of Medicine)
Abstract
Educational attainment (EduYears), a heritable trait often used as a proxy for cognitive ability, is associated with various health and social outcomes. Previous genome-wide association studies (GWASs) on EduYears have been focused on samples of European (EUR) genetic ancestries. Here we present the first large-scale GWAS of EduYears in people of East Asian (EAS) ancestry (n = 176,400) and conduct a cross-ancestry meta-analysis with EduYears GWAS in people of EUR ancestry (n = 766,345). EduYears showed a high genetic correlation and power-adjusted transferability ratio between EAS and EUR. We also found similar functional enrichment, gene expression enrichment and cross-trait genetic correlations between two populations. Cross-ancestry fine-mapping identified refined credible sets with a higher posterior inclusion probability than single population fine-mapping. Polygenic prediction analysis in four independent EAS and EUR cohorts demonstrated transferability between populations. Our study supports the need for further research on diverse ancestries to increase our understanding of the genetic basis of educational attainment.
Suggested Citation
Tzu-Ting Chen & Jaeyoung Kim & Max Lam & Yi-Fang Chuang & Yen-Ling Chiu & Shu-Chin Lin & Sang-Hyuk Jung & Beomsu Kim & Soyeon Kim & Chamlee Cho & Injeong Shim & Sanghyeon Park & Yeeun Ahn & Aysu Okbay, 2024.
"Shared genetic architectures of educational attainment in East Asian and European populations,"
Nature Human Behaviour, Nature, vol. 8(3), pages 562-575, March.
Handle:
RePEc:nat:nathum:v:8:y:2024:i:3:d:10.1038_s41562-023-01781-9
DOI: 10.1038/s41562-023-01781-9
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