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A systematic review and meta-analysis of 90 cohort studies of social isolation, loneliness and mortality

Author

Listed:
  • Fan Wang

    (Harbin Medical University
    Harbin Medical University)

  • Yu Gao

    (Harbin Medical University)

  • Zhen Han

    (Harbin Medical University)

  • Yue Yu

    (Harbin Medical University)

  • Zhiping Long

    (Harbin Medical University)

  • Xianchen Jiang

    (Quzhou Center for Disease Control and Prevention)

  • Yi Wu

    (Harbin Medical University)

  • Bing Pei

    (Harbin Medical University)

  • Yukun Cao

    (Harbin Medical University)

  • Jingyu Ye

    (Harbin Medical University)

  • Maoqing Wang

    (Harbin Medical University)

  • Yashuang Zhao

    (Harbin Medical University
    Harbin Medical University)

Abstract

The associations between social isolation, loneliness and the risk of mortality from all causes, cardiovascular disease (CVD) and cancer are controversial. We systematically reviewed prospective studies on the association between social isolation, loneliness and mortality outcomes in adults aged 18 years or older, as well as studies on these relationships in individuals with CVD or cancer, and conducted a meta-analysis. The study protocol was registered with PROSPERO (reg. no. CRD42022299959). A total of 90 prospective cohort studies including 2,205,199 individuals were included. Here we show that, in the general population, both social isolation and loneliness were significantly associated with an increased risk of all-cause mortality (pooled effect size for social isolation, 1.32; 95% confidence interval (CI), 1.26 to 1.39; P

Suggested Citation

  • Fan Wang & Yu Gao & Zhen Han & Yue Yu & Zhiping Long & Xianchen Jiang & Yi Wu & Bing Pei & Yukun Cao & Jingyu Ye & Maoqing Wang & Yashuang Zhao, 2023. "A systematic review and meta-analysis of 90 cohort studies of social isolation, loneliness and mortality," Nature Human Behaviour, Nature, vol. 7(8), pages 1307-1319, August.
    • Handle: RePEc:nat:nathum:v:7:y:2023:i:8:d:10.1038_s41562-023-01617-6
    DOI: 10.1038/s41562-023-01617-6
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