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Dissection of genetic variation and evidence for pleiotropy in male pattern baldness

Author

Listed:
  • Chloe X. Yap

    (University of Queensland)

  • Julia Sidorenko

    (University of Queensland
    University of Tartu)

  • Yang Wu

    (University of Queensland)

  • Kathryn E. Kemper

    (University of Queensland)

  • Jian Yang

    (University of Queensland
    University of Queensland)

  • Naomi R. Wray

    (University of Queensland
    University of Queensland)

  • Matthew R. Robinson

    (University of Queensland
    University of Lausanne
    Swiss Institute of Bioinformatics)

  • Peter M. Visscher

    (University of Queensland
    University of Queensland)

Abstract

Male pattern baldness (MPB) is a sex-limited, age-related, complex trait. We study MPB genetics in 205,327 European males from the UK Biobank. Here we show that MPB is strongly heritable and polygenic, with pedigree-heritability of 0.62 (SE = 0.03) estimated from close relatives, and SNP-heritability of 0.39 (SE = 0.01) from conventionally-unrelated males. We detect 624 near-independent genome-wide loci, contributing SNP-heritability of 0.25 (SE = 0.01), of which 26 X-chromosome loci explain 11.6%. Autosomal genetic variance is enriched for common variants and regions of lower linkage disequilibrium. We identify plausible genetic correlations between MPB and multiple sex-limited markers of earlier puberty, increased bone mineral density (rg = 0.15) and pancreatic β-cell function (rg = 0.12). Correlations with reproductive traits imply an effect on fitness, consistent with an estimated linear selection gradient of -0.018 per MPB standard deviation. Overall, we provide genetic insights into MPB: a phenotype of interest in its own right, with value as a model sex-limited, complex trait.

Suggested Citation

  • Chloe X. Yap & Julia Sidorenko & Yang Wu & Kathryn E. Kemper & Jian Yang & Naomi R. Wray & Matthew R. Robinson & Peter M. Visscher, 2018. "Dissection of genetic variation and evidence for pleiotropy in male pattern baldness," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07862-y
    DOI: 10.1038/s41467-018-07862-y
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    Cited by:

    1. William J. Young & Najim Lahrouchi & Aaron Isaacs & ThuyVy Duong & Luisa Foco & Farah Ahmed & Jennifer A. Brody & Reem Salman & Raymond Noordam & Jan-Walter Benjamins & Jeffrey Haessler & Leo-Pekka Ly, 2022. "Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    2. Jue-Sheng Ong & Mathias Seviiri & Jean Claude Dusingize & Yeda Wu & Xikun Han & Jianxin Shi & Catherine M. Olsen & Rachel E. Neale & John F. Thompson & Robyn P. M. Saw & Kerwin F. Shannon & Graham J. , 2023. "Uncovering the complex relationship between balding, testosterone and skin cancers in men," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    3. Sabrina Katrin Henne & Rana Aldisi & Sugirthan Sivalingam & Lara Maleen Hochfeld & Oleg Borisov & Peter Michael Krawitz & Carlo Maj & Markus Maria Nöthen & Stefanie Heilmann-Heimbach, 2023. "Analysis of 72,469 UK Biobank exomes links rare variants to male-pattern hair loss," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    4. Markus Scholz & Katrin Horn & Janne Pott & Matthias Wuttke & Andreas Kühnapfel & M. Kamal Nasr & Holger Kirsten & Yong Li & Anselm Hoppmann & Mathias Gorski & Sahar Ghasemi & Man Li & Adrienne Tin & J, 2024. "X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response element," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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