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Injectable antibacterial conductive nanocomposite cryogels with rapid shape recovery for noncompressible hemorrhage and wound healing

Author

Listed:
  • Xin Zhao

    (Xi’an Jiaotong University)

  • Baolin Guo

    (Xi’an Jiaotong University)

  • Hao Wu

    (Xi’an Jiaotong University)

  • Yongping Liang

    (Xi’an Jiaotong University)

  • Peter X. Ma

    (University of Michigan
    University of Michigan
    University of Michigan)

Abstract

Developing injectable antibacterial and conductive shape memory hemostatic with high blood absorption and fast recovery for irregularly shaped and noncompressible hemorrhage remains a challenge. Here we report injectable antibacterial conductive cryogels based on carbon nanotube (CNT) and glycidyl methacrylate functionalized quaternized chitosan for lethal noncompressible hemorrhage hemostasis and wound healing. These cryogels present robust mechanical strength, rapid blood-triggered shape recovery and absorption speed, and high blood uptake capacity. Moreover, cryogels show better blood-clotting ability, higher blood cell and platelet adhesion and activation than gelatin sponge and gauze. Cryogel with 4 mg/mL CNT (QCSG/CNT4) shows better hemostatic capability than gauze and gelatin hemostatic sponge in mouse-liver injury model and mouse-tail amputation model, and better wound healing performance than Tegaderm™ film. Importantly, QCSG/CNT4 presents excellent hemostatic performance in rabbit liver defect lethal noncompressible hemorrhage model and even better hemostatic ability than Combat Gauze in standardized circular liver bleeding model.

Suggested Citation

  • Xin Zhao & Baolin Guo & Hao Wu & Yongping Liang & Peter X. Ma, 2018. "Injectable antibacterial conductive nanocomposite cryogels with rapid shape recovery for noncompressible hemorrhage and wound healing," Nature Communications, Nature, vol. 9(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04998-9
    DOI: 10.1038/s41467-018-04998-9
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    Cited by:

    1. Guangyu Bao & Qiman Gao & Massimo Cau & Nabil Ali-Mohamad & Mitchell Strong & Shuaibing Jiang & Zhen Yang & Amin Valiei & Zhenwei Ma & Marco Amabili & Zu-Hua Gao & Luc Mongeau & Christian Kastrup & Ji, 2022. "Liquid-infused microstructured bioadhesives halt non-compressible hemorrhage," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Yan Cui & Zongwang Huang & Li Lei & Qinglin Li & Jinlong Jiang & Qinghai Zeng & Aidong Tang & Huaming Yang & Yi Zhang, 2021. "Robust hemostatic bandages based on nanoclay electrospun membranes," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    3. Bin Chen & Yudong Cao & Qiaoyu Li & Zhuo Yan & Rui Liu & Yunjiao Zhao & Xiang Zhang & Minying Wu & Yixiu Qin & Chang Sun & Wei Yao & Ziyi Cao & Pulickel M. Ajayan & Mason Oliver Lam Chee & Pei Dong & , 2022. "Liquid metal-tailored gluten network for protein-based e-skin," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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