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Neuronal messenger ribonucleoprotein transport follows an aging Lévy walk

Author

Listed:
  • Minho S. Song

    (Seoul National University)

  • Hyungseok C. Moon

    (Seoul National University)

  • Jae-Hyung Jeon

    (Pohang University of Science and Technology)

  • Hye Yoon Park

    (Seoul National University
    Seoul National University)

Abstract

Localization of messenger ribonucleoproteins (mRNPs) plays an essential role in the regulation of gene expression for long-term memory formation and neuronal development. Knowledge concerning the nature of neuronal mRNP transport is thus crucial for understanding how mRNPs are delivered to their target synapses. Here, we report experimental and theoretical evidence that the active transport dynamics of neuronal mRNPs, which is distinct from the previously reported motor-driven transport, follows an aging Lévy walk. Such nonergodic, transient superdiffusion occurs because of two competing dynamic phases: the motor-involved ballistic run and static localization of mRNPs. Our proposed Lévy walk model reproduces the experimentally extracted key dynamic characteristics of mRNPs with quantitative accuracy. Moreover, the aging status of mRNP particles in an experiment is inferred from the model. This study provides a predictive theoretical model for neuronal mRNP transport and offers insight into the active target search mechanism of mRNP particles in vivo.

Suggested Citation

  • Minho S. Song & Hyungseok C. Moon & Jae-Hyung Jeon & Hye Yoon Park, 2018. "Neuronal messenger ribonucleoprotein transport follows an aging Lévy walk," Nature Communications, Nature, vol. 9(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-017-02700-z
    DOI: 10.1038/s41467-017-02700-z
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    Cited by:

    1. Čukić, Milena & Galovic, Slobodanka, 2023. "Mathematical modeling of anomalous diffusive behavior in transdermal drug-delivery including time-delayed flux concept," Chaos, Solitons & Fractals, Elsevier, vol. 172(C).
    2. Pauline Formaglio & Marina E. Wosniack & Raphael M. Tromer & Jaderson G. Polli & Yuri B. Matos & Hang Zhong & Ernesto P. Raposo & Marcos G. E. Luz & Rogerio Amino, 2023. "Plasmodium sporozoite search strategy to locate hotspots of blood vessel invasion," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    3. Wang, Xudong & Chen, Yao, 2024. "Langevin picture of subdiffusive particles under the joint influence of an expanding medium and an external constant force," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 633(C).

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