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Epigenetic and genetic components of height regulation

Author

Listed:
  • Stefania Benonisdottir

    (deCODE Genetics/Amgen, Inc.)

  • Asmundur Oddsson

    (deCODE Genetics/Amgen, Inc.)

  • Agnar Helgason

    (deCODE Genetics/Amgen, Inc.
    University of Iceland)

  • Ragnar P. Kristjansson

    (deCODE Genetics/Amgen, Inc.)

  • Gardar Sveinbjornsson

    (deCODE Genetics/Amgen, Inc.)

  • Arna Oskarsdottir

    (deCODE Genetics/Amgen, Inc.)

  • Gudmar Thorleifsson

    (deCODE Genetics/Amgen, Inc.)

  • Olafur B. Davidsson

    (deCODE Genetics/Amgen, Inc.)

  • Gudny A. Arnadottir

    (deCODE Genetics/Amgen, Inc.)

  • Gerald Sulem

    (deCODE Genetics/Amgen, Inc.)

  • Brynjar O. Jensson

    (deCODE Genetics/Amgen, Inc.)

  • Hilma Holm

    (deCODE Genetics/Amgen, Inc.)

  • Kristjan F. Alexandersson

    (deCODE Genetics/Amgen, Inc.)

  • Laufey Tryggvadottir

    (Faculty of Medicine, University of Iceland
    Icelandic Cancer Registry)

  • G. Bragi Walters

    (deCODE Genetics/Amgen, Inc.)

  • Sigurjon A. Gudjonsson

    (deCODE Genetics/Amgen, Inc.)

  • Lucas D. Ward

    (deCODE Genetics/Amgen, Inc.)

  • Jon K. Sigurdsson

    (deCODE Genetics/Amgen, Inc.)

  • Paul D. Iordache

    (deCODE Genetics/Amgen, Inc.
    Reykjavik University)

  • Michael L. Frigge

    (deCODE Genetics/Amgen, Inc.)

  • Thorunn Rafnar

    (deCODE Genetics/Amgen, Inc.)

  • Augustine Kong

    (deCODE Genetics/Amgen, Inc.
    School of Engineering and Natural Sciences, University of Iceland)

  • Gisli Masson

    (deCODE Genetics/Amgen, Inc.)

  • Hannes Helgason

    (deCODE Genetics/Amgen, Inc.
    School of Engineering and Natural Sciences, University of Iceland)

  • Unnur Thorsteinsdottir

    (deCODE Genetics/Amgen, Inc.
    Faculty of Medicine, University of Iceland)

  • Daniel F. Gudbjartsson

    (deCODE Genetics/Amgen, Inc.
    School of Engineering and Natural Sciences, University of Iceland)

  • Patrick Sulem

    (deCODE Genetics/Amgen, Inc.)

  • Kari Stefansson

    (deCODE Genetics/Amgen, Inc.
    Faculty of Medicine, University of Iceland)

Abstract

Adult height is a highly heritable trait. Here we identified 31.6 million sequence variants by whole-genome sequencing of 8,453 Icelanders and tested them for association with adult height by imputing them into 88,835 Icelanders. Here we discovered 13 novel height associations by testing four different models including parent-of-origin (|β|=0.4–10.6 cm). The minor alleles of three parent-of-origin signals associate with less height only when inherited from the father and are located within imprinted regions (IGF2-H19 and DLK1-MEG3). We also examined the association of these sequence variants in a set of 12,645 Icelanders with birth length measurements. Two of the novel variants, (IGF2-H19 and TET1), show significant association with both adult height and birth length, indicating a role in early growth regulation. Among the parent-of-origin signals, we observed opposing parental effects raising questions about underlying mechanisms. These findings demonstrate that common variations affect human growth by parental imprinting.

Suggested Citation

  • Stefania Benonisdottir & Asmundur Oddsson & Agnar Helgason & Ragnar P. Kristjansson & Gardar Sveinbjornsson & Arna Oskarsdottir & Gudmar Thorleifsson & Olafur B. Davidsson & Gudny A. Arnadottir & Gera, 2016. "Epigenetic and genetic components of height regulation," Nature Communications, Nature, vol. 7(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms13490
    DOI: 10.1038/ncomms13490
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    Cited by:

    1. Robin J. Hofmeister & Simone Rubinacci & Diogo M. Ribeiro & Alfonso Buil & Zoltán Kutalik & Olivier Delaneau, 2022. "Parent-of-Origin inference for biobanks," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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