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Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus

Author

Listed:
  • Kate Lawrenson

    (Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center
    Present address: Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA)

  • Siddhartha Kar

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Karen McCue

    (QIMR Berghofer Medical Research Institute)

  • Karoline Kuchenbaeker

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Kyriaki Michailidou

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Jonathan Tyrer

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Jonathan Beesley

    (QIMR Berghofer Medical Research Institute)

  • Susan J. Ramus

    (Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center)

  • Qiyuan Li

    (Medical College, Xiamen University
    The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute)

  • Melissa K. Delgado

    (Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center)

  • Janet M. Lee

    (Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center)

  • Kristiina Aittomäki

    (Helsinki University Hospital, University of Helsinki)

  • Irene L. Andrulis

    (Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital
    University of Toronto)

  • Hoda Anton-Culver

    (Genetic Epidemiology Research Institute, School of Medicine, University of California Irvine)

  • Volker Arndt

    (German Cancer Research Center (DKFZ))

  • Banu K. Arun

    (University of Texas MD Anderson Cancer Center)

  • Brita Arver

    (Karolinska University Hospital)

  • Elisa V. Bandera

    (Cancer Prevention and Control, Rutgers Cancer Institute of New Jersey)

  • Monica Barile

    (Istituto Europeo di Oncologia)

  • Rosa B. Barkardottir

    (Landspitali University Hospital and BMC (Biomedical Centre), Faculty of Medicine, University of Iceland)

  • Daniel Barrowdale

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Matthias W. Beckmann

    (University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN)

  • Javier Benitez

    (Human Cancer Genetics Program, Spanish National Cancer Research Centre
    Centro de Investigación en Red de Enfermedades Raras)

  • Andrew Berchuck

    (Duke University Medical Center)

  • Maria Bisogna

    (Gynecology Service, Memorial Sloan-Kettering Cancer Center)

  • Line Bjorge

    (Haukeland University Hospital
    Centre for Cancer Biomarkers, University of Bergen)

  • Carl Blomqvist

    (Helsinki University Hospital, University of Helsinki)

  • William Blot

    (Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine
    International Epidemiology Institute)

  • Natalia Bogdanova

    (Gynaecology Research Unit, Hannover Medical School)

  • Anders Bojesen

    (Vejle Hospital)

  • Stig E. Bojesen

    (Faculty of Health and Medical Sciences, University of Copenhagen
    Herlev Hospital, Copenhagen University Hospital
    Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital)

  • Manjeet K. Bolla

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Bernardo Bonanni

    (Istituto Europeo di Oncologia)

  • Anne-Lise Børresen-Dale

    (Institute for Cancer Research, Oslo University Hospital Radiumhospitalet
    K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo)

  • Hiltrud Brauch

    (Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology
    University of Tübingen
    German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ))

  • Paul Brennan

    (International Agency for Research on Cancer)

  • Hermann Brenner

    (German Cancer Research Center (DKFZ)
    German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)
    German Cancer Research Center (DKFZ))

  • Fiona Bruinsma

    (Cancer Epidemiology Centre, Cancer Council Victoria)

  • Joan Brunet

    (Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigació Biomèdica de Girona), Catalan Institute of Oncology)

  • Shaik Ahmad Buhari

    (National University Health System)

  • Barbara Burwinkel

    (Molecular Epidemiology Group, German Cancer Research Center (DKFZ)
    University of Heidelberg)

  • Ralf Butzow

    (University of Helsinki and Helsinki University Central Hospital
    Helsinki University Central Hospital)

  • Saundra S. Buys

    (Huntsman Cancer Institute, University of Utah School of Medicine)

  • Qiuyin Cai

    (Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine)

  • Trinidad Caldes

    (Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos))

  • Ian Campbell

    (Cancer Genetics Laboratory, Peter MacCallum Cancer Centre)

  • Rikki Canniotto

    (Cancer Pathology & Prevention, Roswell Park Cancer Institute)

  • Jenny Chang-Claude

    (German Cancer Research Center (DKFZ)
    University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf)

  • Jocelyne Chiquette

    (Unité de recherche en santé des populations, Centre des maladies du sein Deschênes-Fabia, Centre de recherche FRSQ du Centre hospitalier affilié universitaire de Québec)

  • Ji-Yeob Choi

    (Cancer Research Institute, Seoul National University
    Seoul National University College of Medicine)

  • Kathleen B. M. Claes

    (Center for Medical Genetics, Ghent University)

  • Linda S. Cook

    (University of New Mexico)

  • Angela Cox

    (Sheffield Cancer Research, University of Sheffield)

  • Daniel W. Cramer

    (Harvard HT Chan School of Public Health
    Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School)

  • Simon S. Cross

    (Academic Unit of Pathology, University of Sheffield)

  • Cezary Cybulski

    (Pomeranian Medical University)

  • Kamila Czene

    (Karolinska Institutet)

  • Mary B. Daly

    (Fox Chase Cancer Center)

  • Francesca Damiola

    (INSERM U1052, CNRS UMR5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon)

  • Agnieszka Dansonka-Mieszkowska

    (Department of Pathology and Laboratory Diagnostics the Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology)

  • Hatef Darabi

    (Karolinska Institutet)

  • Joe Dennis

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Peter Devilee

    (Leiden University Medical Center
    Leiden University Medical Center)

  • Orland Diez

    (Oncogenetics Group, University Hospital Vall d’Hebron, Vall d’Hebron Institute of Oncology (VHIO) and Universitat Autònoma de Barcelona)

  • Jennifer A. Doherty

    (Section of Biostatistics & Epidemiology, The Geisel School of Medicine at Dartmouth)

  • Susan M. Domchek

    (Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania)

  • Cecilia M. Dorfling

    (University of Pretoria)

  • Thilo Dörk

    (Gynaecology Research Unit, Hannover Medical School)

  • Martine Dumont

    (Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University)

  • Hans Ehrencrona

    (Genetics and Pathology, Uppsala University
    Lund University Hospital)

  • Bent Ejlertsen

    (Rigshospitalet, Copenhagen University Hospital)

  • Steve Ellis

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Christoph Engel

    (Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig)

  • Eunjung Lee

    (Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center)

  • D. Gareth Evans

    (Genomic Medicine, Manchester Academic Health Sciences Centre, Institute of Human Development, Manchester University, Central Manchester University Hospitals NHS Foundation Trust)

  • Peter A. Fasching

    (University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN
    University of California at Los Angeles, David Geffen School of Medicine)

  • Lidia Feliubadalo

    (Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute),Catalan Institute of Oncology)

  • Jonine Figueroa

    (National Cancer Institute)

  • Dieter Flesch-Janys

    (Institute for Medical Biometrics and Epidemiology, University Medical Center Hamburg-Eppendorf
    Clinical Cancer Registry, University Medical Center Hamburg-Eppendorf)

  • Olivia Fletcher

    (Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research
    The Institute of Cancer Research)

  • Henrik Flyger

    (Herlev Hospital, Copenhagen University Hospital)

  • Lenka Foretova

    (Masaryk Memorial Cancer Institute and Medical Faculty MU)

  • Florentia Fostira

    (Molecular Diagnostics Laboratory, (INRASTES) Institute of Nuclear and Radiological Sciences and Technology, National Centre for Scientific Research ‘Demokritos’, Aghia Paraskevi Attikis)

  • William D. Foulkes

    (Program in Cancer Genetics, McGill University, Montreal)

  • Brooke L. Fridley

    (Biostatistics and Informatics Shared Resource, University of Kansas Medical Center)

  • Eitan Friedman

    (Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center)

  • Debra Frost

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Gaetana Gambino

    (Section of Genetic Oncology, University and University Hospital of Pisa)

  • Patricia A. Ganz

    (UCLA Schools of Medicine and Public Health, Jonsson Comprehensive Cancer Center)

  • Judy Garber

    (Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute)

  • Montserrat García-Closas

    (National Cancer Institute
    The Institute of Cancer Research)

  • Aleksandra Gentry-Maharaj

    (Women's Cancer, UCL EGA Institute for Women's Health)

  • Maya Ghoussaini

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Graham G. Giles

    (Cancer Epidemiology Centre, Cancer Council Victoria
    Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne)

  • Rosalind Glasspool

    (Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre)

  • Andrew K. Godwin

    (University of Kansas Medical Center)

  • Mark S. Goldberg

    (Royal Victoria Hospital, McGill University
    McGill University)

  • David E. Goldgar

    (Huntsman Cancer Institute, University of Utah School of Medicine)

  • Anna González-Neira

    (Human Cancer Genetics Program, Spanish National Cancer Research Centre)

  • Ellen L. Goode

    (Mayo Clinic)

  • Marc T. Goodman

    (Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
    Community and Population Health Research Institute, Cedars-Sinai Medical Center)

  • Mark H. Greene

    (Clinical Genetics Branch, National Cancer Institute, National Institutes of Health)

  • Jacek Gronwald

    (Pomeranian Medical University)

  • Pascal Guénel

    (Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM
    University Paris-Sud)

  • Christopher A. Haiman

    (Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center)

  • Per Hall

    (Karolinska Institutet)

  • Emily Hallberg

    (Mayo Clinic)

  • Ute Hamann

    (Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ))

  • Thomas V. O. Hansen

    (Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital)

  • Patricia A. Harrington

    (University of Cambridge, Strangeways Research Laboratory)

  • Mikael Hartman

    (National University Health System
    Saw Swee Hock School of Public Health, National University of Singapore)

  • Norhashimah Hassan

    (Breast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre
    Cancer Research Initiatives Foundation, Subang Jaya)

  • Sue Healey

    (QIMR Berghofer Medical Research Institute)

  • Florian Heitz

    (Kliniken Essen-Mitte
    Dr Horst Schmidt Kliniken Wiesbaden)

  • Josef Herzog

    (Clinical Cancer Genetics, for the City of Hope Clinical Cancer Genetics Community Research Network)

  • Estrid Høgdall

    (Molecular Unit, Herlev Hospital, University of Copenhagen
    Lifestyle and Genes, Danish Cancer Society Research Center)

  • Claus K. Høgdall

    (Rigshospitalet, University of Copenhagen)

  • Frans B. L. Hogervorst

    (Family Cancer Clinic, Netherlands Cancer Institute)

  • Antoinette Hollestelle

    (Family Cancer Clinic, Erasmus MC Cancer Institute)

  • John L. Hopper

    (Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne)

  • Peter J. Hulick

    (Center for Medical Genetics, NorthShore University Health System)

  • Tomasz Huzarski

    (Pomeranian Medical University)

  • Evgeny N. Imyanitov

    (N.N. Petrov Institute of Oncology)

  • Claudine Isaacs

    (Lombardi Comprehensive Cancer Center, Georgetown University)

  • Hidemi Ito

    (Aichi Cancer Center Research Institute)

  • Anna Jakubowska

    (Pomeranian Medical University)

  • Ramunas Janavicius

    (State Research Institute Centre for Innovative Medicine)

  • Allan Jensen

    (Rigshospitalet, University of Copenhagen)

  • Esther M. John

    (Cancer Prevention Institute of California)

  • Nichola Johnson

    (Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research
    The Institute of Cancer Research)

  • Maria Kabisch

    (Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ))

  • Daehee Kang

    (Cancer Research Institute, Seoul National University
    Seoul National University College of Medicine
    Seoul National University College of Medicine)

  • Miroslav Kapuscinski

    (Centre for Epidemiology and Biostatistics, University of Melbourne)

  • Beth Y. Karlan

    (Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center)

  • Sofia Khan

    (University of Helsinki and Helsinki University Central Hospital)

  • Lambertus A. Kiemeney

    (Radboud University Medical Centre, Radboud Institute for Health Sciences)

  • Susanne Kruger Kjaer

    (Lifestyle and Genes, Danish Cancer Society Research Center
    Rigshospitalet, University of Copenhagen)

  • Julia A. Knight

    (Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital
    Dalla Lana School of Public Health, University of Toronto)

  • Irene Konstantopoulou

    (Molecular Diagnostics Laboratory, (INRASTES) Institute of Nuclear and Radiological Sciences and Technology, National Centre for Scientific Research ‘Demokritos’, Aghia Paraskevi Attikis)

  • Veli-Matti Kosma

    (Imaging Center, Kuopio University Hospital
    Cancer Center, Kuopio University Hospital
    Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland)

  • Vessela Kristensen

    (Institute for Cancer Research, Oslo University Hospital Radiumhospitalet
    K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo
    Oslo University Hospital, University of Oslo)

  • Jolanta Kupryjanczyk

    (Department of Pathology and Laboratory Diagnostics the Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology)

  • Ava Kwong

    (The Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Center, Hong Kong Sanatorium and Hospital
    The University of Hong Kong)

  • Miguel de la Hoya

    (Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos))

  • Yael Laitman

    (Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center)

  • Diether Lambrechts

    (Vesalius Research Center, VIB
    Laboratory for Translational Genetics, University of Leuven)

  • Nhu Le

    (Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center)

  • Kim De Leeneer

    (Center for Medical Genetics, Ghent University)

  • Jenny Lester

    (Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center)

  • Douglas A. Levine

    (Gynecology Service, Memorial Sloan-Kettering Cancer Center)

  • Jingmei Li

    (Karolinska Institutet)

  • Annika Lindblom

    (Karolinska Institutet)

  • Jirong Long

    (Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine)

  • Artitaya Lophatananon

    (Warwick Medical School, Warwick University)

  • Jennifer T. Loud

    (Clinical Genetics Branch, National Cancer Institute, National Institutes of Health)

  • Karen Lu

    (The University of Texas MD Anderson Cancer Center)

  • Jan Lubinski

    (Pomeranian Medical University)

  • Arto Mannermaa

    (Imaging Center, Kuopio University Hospital
    Cancer Center, Kuopio University Hospital
    Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland)

  • Siranoush Manoukian

    (Unit of Medical Genetics, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT))

  • Loic Le Marchand

    (University of Hawaii Cancer Center)

  • Sara Margolin

    (Karolinska Institutet)

  • Frederik Marme

    (University of Heidelberg
    National Center for Tumour Diseases, University of Heidelberg)

  • Leon F. A. G. Massuger

    (Radboud University Medical Centre)

  • Keitaro Matsuo

    (Kyushu University Faculty of Medical Sciences)

  • Sylvie Mazoyer

    (INSERM U1052, CNRS UMR5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon)

  • Lesley McGuffog

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Catriona McLean

    (Anatomical Pathology, The Alfred Hospital)

  • Iain McNeish

    (Institute of Cancer Sciences, University of Glasgow, Wolfson Wohl Cancer Research Centre, Beatson Institute for Cancer Research)

  • Alfons Meindl

    (Technische Universität München)

  • Usha Menon

    (Women's Cancer, UCL EGA Institute for Women's Health)

  • Arjen R. Mensenkamp

    (Radboud University Medical Centre)

  • Roger L. Milne

    (Cancer Epidemiology Centre, Cancer Council Victoria
    Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne)

  • Marco Montagna

    (Immunology and Molecular Oncology Unit, Instituto Oncologico Veneto IOV, IRCCS)

  • Kirsten B. Moysich

    (Roswell Park Cancer Institute)

  • Kenneth Muir

    (Warwick Medical School, Warwick University
    Institute of Population Health, University of Manchester)

  • Anna Marie Mulligan

    (Laboratory Medicine Program, University Health Network
    University of Toronto)

  • Katherine L. Nathanson

    (Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania)

  • Roberta B. Ness

    (The University of Texas School of Public Health)

  • Susan L. Neuhausen

    (Beckman Research Institute of City of Hope)

  • Heli Nevanlinna

    (University of Helsinki and Helsinki University Central Hospital)

  • Silje Nord

    (K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo)

  • Robert L. Nussbaum

    (University of California)

  • Kunle Odunsi

    (Roswell Park Cancer Institute)

  • Kenneth Offit

    (Memorial Sloan-Kettering Cancer Center)

  • Edith Olah

    (National Institute of Oncology)

  • Olufunmilayo I. Olopade

    (Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center)

  • Janet E. Olson

    (Mayo Clinic)

  • Curtis Olswold

    (Mayo Clinic)

  • David O’Malley

    (The Ohio State University and the James Cancer Center)

  • Irene Orlow

    (Memorial Sloan Kettering Cancer Center)

  • Nick Orr

    (Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research)

  • Ana Osorio

    (Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO)
    Biomedical Network on Rare Diseases (CIBERER))

  • Sue Kyung Park

    (Seoul National University College of Medicine
    Seoul National University College of Medicine
    Seoul National University College of Medicine)

  • Celeste L. Pearce

    (Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center)

  • Tanja Pejovic

    (Oregon Health and Science University
    Knight Cancer Institute, Oregon Health and Science University)

  • Paolo Peterlongo

    (IFOM, The FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology)

  • Georg Pfeiler

    (Comprehensive Cancer Center, Medical University of Vienna)

  • Catherine M. Phelan

    (Moffitt Cancer Center)

  • Elizabeth M. Poole

    (Brigham and Women's Hospital and Harvard Medical School
    Harvard TH Chan School of Public Health)

  • Katri Pylkäs

    (Laboratory of Cancer Genetics and Tumour Biology, Northern Finland Laboratory Centre NordLab
    Laboratory of Cancer Genetics and Tumour Biology, University of Oulu)

  • Paolo Radice

    (Unit of Molecular Bases of Genetic Risk and Genetic Testing, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT))

  • Johanna Rantala

    (Karolinska University Hospital)

  • Muhammad Usman Rashid

    (Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)
    Shaukat Khanum Memorial Cancer Hospital and Research Centre (SKMCH & RC))

  • Gad Rennert

    (Carmel Medical Center and B. Rappaport Faculty of Medicine)

  • Valerie Rhenius

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Kerstin Rhiem

    (Centre of Familial Breast and Ovarian Cancer, Center for Molecular Medicine Cologne (CMMC), University Hospital of Cologne)

  • Harvey A. Risch

    (Yale School of Public Health)

  • Gus Rodriguez

    (NorthShore University HealthSystem)

  • Mary Anne Rossing

    (Program in Epidemiology, Fred Hutchinson Cancer Research Center
    University of Washington)

  • Anja Rudolph

    (German Cancer Research Center (DKFZ))

  • Helga B. Salvesen

    (Haukeland University Hospital
    Centre for Cancer Biomarkers, University of Bergen)

  • Suleeporn Sangrajrang

    (National Cancer Institute)

  • Elinor J. Sawyer

    (Research Oncology, Guy’s Hospital, King's College London)

  • Joellen M. Schildkraut

    (Duke University Medical Center
    Cancer Control and Population Sciences, Duke Cancer Institute)

  • Marjanka K. Schmidt

    (Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital)

  • Rita K. Schmutzler

    (University Hospital of Cologne
    Center for Integrated Oncology, University Hospital of Cologne
    Center for Molecular Medicine, University Hospital of Cologne
    Center of Familial Breast and Ovarian Cancer, University Hospital of Cologne)

  • Thomas A. Sellers

    (Moffitt Cancer Center)

  • Caroline Seynaeve

    (Family Cancer Clinic, Erasmus MC Cancer Institute)

  • Mitul Shah

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Chen-Yang Shen

    (Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica
    School of Public Health, China Medical University)

  • Xiao-Ou Shu

    (Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine)

  • Weiva Sieh

    (Stanford University School of Medicine)

  • Christian F. Singer

    (Comprehensive Cancer Center, Medical University of Vienna)

  • Olga M. Sinilnikova

    (Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon – Centre Léon Bérard
    INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon)

  • Susan Slager

    (Mayo Clinic)

  • Honglin Song

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Penny Soucy

    (Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University)

  • Melissa C. Southey

    (University of Melbourne)

  • Marie Stenmark-Askmalm

    (Lund University Hospital
    Linköping University)

  • Dominique Stoppa-Lyonnet

    (Institut Curie, Paris, France
    Institut Curie, INSERM U830
    Université Paris Descartes, Sorbonne Paris Cité)

  • Christian Sutter

    (Institute of Human Genetics, University Hospital Heidelberg)

  • Anthony Swerdlow

    (The Institute of Cancer Research
    The Institute of Cancer Research)

  • Sandrine Tchatchou

    (Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital)

  • Manuel R. Teixeira

    (Portuguese Oncology Institute
    Biomedical Sciences Institute (ICBAS), Porto University)

  • Soo H. Teo

    (Breast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre
    Cancer Research Initiatives Foundation, Subang Jaya)

  • Kathryn L. Terry

    (Harvard HT Chan School of Public Health
    Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School)

  • Mary Beth Terry

    (Mailman School of Public Health, Columbia University)

  • Mads Thomassen

    (Odense University Hospital)

  • Maria Grazia Tibiletti

    (UO Anatomia Patologica, Ospedale di Circolo-Università dell'Insubria)

  • Laima Tihomirova

    (Latvian Biomedical Research and Study Centre)

  • Silvia Tognazzo

    (Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV - IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico))

  • Amanda Ewart Toland

    (Immunology and Medical Genetics, The Ohio State University)

  • Ian Tomlinson

    (Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford)

  • Diana Torres

    (Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)
    Institute of Human Genetics, Pontificia Universidad Javeriana, Cra. 7 #40-62)

  • Thérèse Truong

    (Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM
    University Paris-Sud)

  • Chiu-chen Tseng

    (Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center)

  • Nadine Tung

    (Beth Israel Deaconess Medical Center)

  • Shelley S. Tworoger

    (Brigham and Women's Hospital and Harvard Medical School
    Harvard TH Chan School of Public Health)

  • Celine Vachon

    (Mayo Clinic)

  • Ans M. W. van den Ouweland

    (Erasmus University Medical Center)

  • Helena C. van Doorn

    (Family Cancer Clinic, Erasmus MC Cancer Institute)

  • Elizabeth J. van Rensburg

    (University of Pretoria)

  • Laura J. Van't Veer

    (Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital)

  • Adriaan Vanderstichele

    (University Hospitals Leuven)

  • Ignace Vergote

    (University Hospitals Leuven)

  • Joseph Vijai

    (Memorial Sloan-Kettering Cancer Center)

  • Qin Wang

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Shan Wang-Gohrke
  • Jeffrey N. Weitzel

    (Clinical Cancer Genetics, for the City of Hope Clinical Cancer Genetics Community Research Network)

  • Nicolas Wentzensen

    (National Cancer Institute)

  • Alice S. Whittemore

    (Stanford University School of Medicine)

  • Hans Wildiers

    (Multidisciplinary Breast Center, University Hospitals Leuven)

  • Robert Winqvist

    (Laboratory of Cancer Genetics and Tumour Biology, Northern Finland Laboratory Centre NordLab
    Laboratory of Cancer Genetics and Tumour Biology, University of Oulu)

  • Anna H. Wu

    (Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center)

  • Drakoulis Yannoukakos

    (Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research ‘Demokritos’)

  • Sook-Yee Yoon

    (Cancer Research Initiatives Foundation, Sime Darby Medical Centre
    University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya)

  • Jyh-Cherng Yu

    (Tri-Service General Hospital, National Defense Medical Center)

  • Wei Zheng

    (Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine)

  • Ying Zheng

    (Shanghai Center for Disease Control and Prevention)

  • Kum Kum Khanna

    (QIMR Berghofer Medical Research Institute)

  • Jacques Simard

    (Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University)

  • Alvaro N. Monteiro

    (Cancer Epidemiology Program, H. Lee Moffitt Cancer Center & Research Institute)

  • Juliet D. French

    (QIMR Berghofer Medical Research Institute)

  • Fergus J. Couch

    (Mayo Clinic
    Mayo Clinic)

  • Matthew L. Freedman

    (The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute)

  • Douglas F. Easton

    (Centre for Cancer Genetic Epidemiology, University of Cambridge
    Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Alison M. Dunning

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Paul D. Pharoah

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Stacey L. Edwards

    (QIMR Berghofer Medical Research Institute)

  • Georgia Chenevix-Trench

    (QIMR Berghofer Medical Research Institute)

  • Antonis C. Antoniou

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Simon A. Gayther

    (Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center
    Present address: The Center for Bioinformatics and Functional Genomics, Cedars-Sinai Medical Center, Los Angeles, CA, USA)

Abstract

A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 × 10−20), ER-negative BC (P=1.1 × 10−13), BRCA1-associated BC (P=7.7 × 10−16) and triple negative BC (P-diff=2 × 10−5). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P=2 × 10−3) and ABHD8 (P

Suggested Citation

  • Kate Lawrenson & Siddhartha Kar & Karen McCue & Karoline Kuchenbaeker & Kyriaki Michailidou & Jonathan Tyrer & Jonathan Beesley & Susan J. Ramus & Qiyuan Li & Melissa K. Delgado & Janet M. Lee & Krist, 2016. "Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus," Nature Communications, Nature, vol. 7(1), pages 1-22, November.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12675
    DOI: 10.1038/ncomms12675
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