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Functional classification of memory CD8+ T cells by CX3CR1 expression

Author

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  • Jan P. Böttcher

    (Institute of Experimental Immunology, Universitätsklinikum Bonn
    Present address: Immunobiology Laboratory, Francis Crick Institute, Lincoln’s Inn Fields Laboratory, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK.)

  • Marc Beyer

    (Genomics and Immunoregulation, LIMES-Institute, Universität Bonn)

  • Felix Meissner

    (Max Planck Institute of Biochemistry)

  • Zeinab Abdullah

    (Institute of Experimental Immunology, Universitätsklinikum Bonn)

  • Jil Sander

    (Genomics and Immunoregulation, LIMES-Institute, Universität Bonn)

  • Bastian Höchst

    (Institute of Molecular Immunology and Experimental Oncology, Technische Universität München)

  • Sarah Eickhoff

    (Institute of Experimental Immunology, Universitätsklinikum Bonn)

  • Jan C. Rieckmann

    (Max Planck Institute of Biochemistry)

  • Caroline Russo

    (Institute of Virology, Technische Universität München)

  • Tanja Bauer

    (Institute of Virology, Technische Universität München)

  • Tobias Flecken

    (Clinic for Internal Medicine II, Universitätsklinikum Freiburg)

  • Dominik Giesen

    (Clinic for Internal Medicine II, Universitätsklinikum Freiburg)

  • Daniel Engel

    (Institute of Experimental Immunology, Universitätsklinikum Bonn)

  • Steffen Jung

    (Weizmann Institute of Science)

  • Dirk H. Busch

    (Institute of Microbiology, Immunology and Hygiene, Technische Universität München)

  • Ulrike Protzer

    (Institute of Virology, Technische Universität München)

  • Robert Thimme

    (Clinic for Internal Medicine II, Universitätsklinikum Freiburg)

  • Matthias Mann

    (Max Planck Institute of Biochemistry)

  • Christian Kurts

    (Institute of Experimental Immunology, Universitätsklinikum Bonn)

  • Joachim L. Schultze

    (Genomics and Immunoregulation, LIMES-Institute, Universität Bonn)

  • Wolfgang Kastenmüller

    (Institute of Experimental Immunology, Universitätsklinikum Bonn)

  • Percy A. Knolle

    (Institute of Experimental Immunology, Universitätsklinikum Bonn
    Institute of Molecular Immunology and Experimental Oncology, Technische Universität München)

Abstract

Localization of memory CD8+ T cells to lymphoid or peripheral tissues is believed to correlate with proliferative capacity or effector function. Here we demonstrate that the fractalkine-receptor/CX3CR1 distinguishes memory CD8+ T cells with cytotoxic effector function from those with proliferative capacity, independent of tissue-homing properties. CX3CR1-based transcriptome and proteome-profiling defines a core signature of memory CD8+ T cells with effector function. We find CD62LhiCX3CR1+ memory T cells that reside within lymph nodes. This population shows distinct migration patterns and positioning in proximity to pathogen entry sites. Virus-specific CX3CR1+ memory CD8+ T cells are scarce during chronic infection in humans and mice but increase when infection is controlled spontaneously or by therapeutic intervention. This CX3CR1-based functional classification will help to resolve the principles of protective CD8+ T-cell memory.

Suggested Citation

  • Jan P. Böttcher & Marc Beyer & Felix Meissner & Zeinab Abdullah & Jil Sander & Bastian Höchst & Sarah Eickhoff & Jan C. Rieckmann & Caroline Russo & Tanja Bauer & Tobias Flecken & Dominik Giesen & Dan, 2015. "Functional classification of memory CD8+ T cells by CX3CR1 expression," Nature Communications, Nature, vol. 6(1), pages 1-17, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms9306
    DOI: 10.1038/ncomms9306
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    Cited by:

    1. Jing Liu & Xia Bu & Chen Chu & Xiaoming Dai & John M. Asara & Piotr Sicinski & Gordon J. Freeman & Wenyi Wei, 2023. "PRMT1 mediated methylation of cGAS suppresses anti-tumor immunity," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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