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A narrow window of cortical tension guides asymmetric spindle positioning in the mouse oocyte

Author

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  • A. Chaigne

    (CIRB, Collège de France, and CNRS-UMR7241 and INSERM-U1050, Equipe labellisée Ligue contre le Cancer)

  • C. Campillo

    (Université Evry Val d’Essonne, LAMBE, Boulevard F Mitterrand)

  • N. S. Gov

    (Weizmann Institute of Science)

  • R. Voituriez

    (UMR7600-CNRS/UPMC, 4 Place Jussieu)

  • C. Sykes

    (CNRS-UMR168
    UPMC, 4 Place Jussieu
    Institut Curie, Centre de Recherche, Laboratoire Physico-Chimie)

  • M. H. Verlhac

    (CIRB, Collège de France, and CNRS-UMR7241 and INSERM-U1050, Equipe labellisée Ligue contre le Cancer)

  • M. E. Terret

    (CIRB, Collège de France, and CNRS-UMR7241 and INSERM-U1050, Equipe labellisée Ligue contre le Cancer)

Abstract

Cell mechanics control the outcome of cell division. In mitosis, external forces applied on a stiff cortex direct spindle orientation and morphogenesis. During oocyte meiosis on the contrary, spindle positioning depends on cortex softening. How changes in cortical organization induce cortex softening has not yet been addressed. Furthermore, the range of tension that allows spindle migration remains unknown. Here, using artificial manipulation of mouse oocyte cortex as well as theoretical modelling, we show that cortical tension has to be tightly regulated to allow off-center spindle positioning: a too low or too high cortical tension both lead to unsuccessful spindle migration. We demonstrate that the decrease in cortical tension required for spindle positioning is fine-tuned by a branched F-actin network that triggers the delocalization of myosin-II from the cortex, which sheds new light on the interplay between actin network architecture and cortex tension.

Suggested Citation

  • A. Chaigne & C. Campillo & N. S. Gov & R. Voituriez & C. Sykes & M. H. Verlhac & M. E. Terret, 2015. "A narrow window of cortical tension guides asymmetric spindle positioning in the mouse oocyte," Nature Communications, Nature, vol. 6(1), pages 1-10, May.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7027
    DOI: 10.1038/ncomms7027
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    Cited by:

    1. Camelia G. Muresan & Zachary Gao Sun & Vikrant Yadav & A. Pasha Tabatabai & Laura Lanier & June Hyung Kim & Taeyoon Kim & Michael P. Murrell, 2022. "F-actin architecture determines constraints on myosin thick filament motion," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Rayane Dibsy & Erwan Bremaud & Johnson Mak & Cyril Favard & Delphine Muriaux, 2023. "HIV-1 diverts cortical actin for particle assembly and release," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Özge Özgüç & Ludmilla de Plater & Varun Kapoor & Anna Francesca Tortorelli & Andrew G Clark & Jean-Léon Maître, 2022. "Cortical softening elicits zygotic contractility during mouse preimplantation development," PLOS Biology, Public Library of Science, vol. 20(3), pages 1-23, March.
    4. Robin M. Skory & Adam A. Moverley & Goli Ardestani & Yanina Alvarez & Ana Domingo-Muelas & Oz Pomp & Blake Hernandez & Piotr Tetlak & Stephanie Bissiere & Claudio D. Stern & Denny Sakkas & Nicolas Pla, 2023. "The nuclear lamina couples mechanical forces to cell fate in the preimplantation embryo via actin organization," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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