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A genome-wide association study of marginal zone lymphoma shows association to the HLA region

Author

Listed:
  • Joseph Vijai

    (Memorial Sloan-Kettering Cancer Center)

  • Zhaoming Wang

    (Cancer Genomics Research Laboratory, National Cancer Institute)

  • Sonja I. Berndt

    (National Cancer Institute)

  • Christine F. Skibola

    (School of Public Health and Comprehensive Cancer Center
    University of California Berkeley School of Public Health)

  • Susan L. Slager

    (Mayo Clinic)

  • Silvia de Sanjose

    (Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d’Oncologia, IDIBELL
    Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP))

  • Mads Melbye

    (Statens Serum Institut
    Stanford University School of Medicine)

  • Bengt Glimelius

    (Karolinska Institutet, Karolinska University Hospital Solna
    Oncology and Radiation Science, Uppsala University)

  • Paige M. Bracci

    (University of California San Francisco)

  • Lucia Conde

    (School of Public Health and Comprehensive Cancer Center
    University of California Berkeley School of Public Health)

  • Brenda M. Birmann

    (Brigham and Women’s Hospital and Harvard Medical School)

  • Sophia S. Wang

    (City of Hope Beckman Research Institute)

  • Angela R. Brooks-Wilson

    (Genome Sciences Centre, BC Cancer Agency
    Simon Fraser University)

  • Qing Lan

    (National Cancer Institute)

  • Paul I. W. de Bakker

    (Center for Molecular Medicine, University Medical Center Utrecht
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht)

  • Roel C. H. Vermeulen

    (Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht
    Institute for Risk Assessment Sciences, Utrecht University)

  • Carol Portlock

    (Memorial Sloan-Kettering Cancer Center)

  • Stephen M. Ansell

    (Mayo Clinic)

  • Brian K. Link

    (Carver College of Medicine, The University of Iowa)

  • Jacques Riby

    (School of Public Health and Comprehensive Cancer Center
    University of California Berkeley School of Public Health)

  • Kari E. North

    (University of North Carolina at Chapel Hill
    Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill)

  • Jian Gu

    (M.D. Anderson Cancer Center)

  • Henrik Hjalgrim

    (Statens Serum Institut)

  • Wendy Cozen

    (USC Keck School of Medicine, University of Southern California
    Norris Comprehensive Cancer Center, USC Keck School of Medicine, University of Southern California)

  • Nikolaus Becker

    (German Cancer Research Center (DKFZ))

  • Lauren R. Teras

    (Epidemiology Research Program, American Cancer Society)

  • John J. Spinelli

    (Cancer Control Research, BC Cancer Agency
    School of Population and Public Health, University of British Columbia)

  • Jenny Turner

    (Pathology, Australian School of Advanced Medicine, Macquarie University
    Douglass Hanly Moir Pathology)

  • Yawei Zhang

    (Yale School of Public Health)

  • Mark P. Purdue

    (National Cancer Institute)

  • Graham G. Giles

    (Cancer Epidemiology Centre, Cancer Council Victoria
    Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne)

  • Rachel S. Kelly

    (MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London)

  • Anne Zeleniuch-Jacquotte

    (New York University School of Medicine
    Cancer Institute, New York University School of Medicine)

  • Maria Grazia Ennas

    (University of Cagliari)

  • Alain Monnereau

    (Environmental Epidemiology of Cancer Group, Inserm, Centre for research in Epidemiology and Population Health (CESP), U1018
    UMRS 1018, Univ Paris Sud
    Registre des hémopathies malignes de la Gironde, Institut Bergonié)

  • Kimberly A. Bertrand

    (Brigham and Women’s Hospital and Harvard Medical School
    Harvard School of Public Health)

  • Demetrius Albanes

    (National Cancer Institute)

  • Tracy Lightfoot

    (University of York)

  • Meredith Yeager

    (Cancer Genomics Research Laboratory, National Cancer Institute)

  • Charles C. Chung

    (National Cancer Institute)

  • Laurie Burdett

    (Cancer Genomics Research Laboratory, National Cancer Institute)

  • Amy Hutchinson

    (Cancer Genomics Research Laboratory, National Cancer Institute)

  • Charles Lawrence

    (Health Studies Sector, Westat)

  • Rebecca Montalvan

    (Health Studies Sector, Westat)

  • Liming Liang

    (Harvard School of Public Health
    Harvard School of Public Health)

  • Jinyan Huang

    (Harvard School of Public Health)

  • Baoshan Ma

    (Harvard School of Public Health
    College of Information Science and Technology, Dalian Maritime University)

  • Danylo J. Villano

    (Memorial Sloan-Kettering Cancer Center)

  • Ann Maria

    (Memorial Sloan-Kettering Cancer Center)

  • Marina Corines

    (Memorial Sloan-Kettering Cancer Center)

  • Tinu Thomas

    (Memorial Sloan-Kettering Cancer Center)

  • Anne J. Novak

    (Mayo Clinic)

  • Ahmet Dogan

    (Memorial Sloan-Kettering Cancer Center)

  • Mark Liebow

    (Mayo Clinic)

  • Carrie A. Thompson

    (Mayo Clinic)

  • Thomas E. Witzig

    (Mayo Clinic)

  • Thomas M. Habermann

    (Mayo Clinic)

  • George J. Weiner

    (Carver College of Medicine, The University of Iowa)

  • Martyn T. Smith

    (University of California Berkeley School of Public Health)

  • Elizabeth A. Holly

    (University of California San Francisco)

  • Rebecca D. Jackson

    (Diabetes and Metabolism, The Ohio State University)

  • Lesley F. Tinker

    (Fred Hutchinson Cancer Research Center)

  • Yuanqing Ye

    (M.D. Anderson Cancer Center)

  • Hans-Olov Adami

    (Harvard School of Public Health
    Karolinska Institutet)

  • Karin E. Smedby

    (Karolinska Institutet)

  • Anneclaire J. De Roos

    (Fred Hutchinson Cancer Research Center
    Drexel University School of Public Health)

  • Patricia Hartge

    (National Cancer Institute)

  • Lindsay M. Morton

    (National Cancer Institute)

  • Richard K. Severson

    (Wayne State University)

  • Yolanda Benavente

    (Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d’Oncologia, IDIBELL
    Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP))

  • Paolo Boffetta

    (The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai)

  • Paul Brennan

    (Group of Genetic Epidemiology, Section of Genetics, International Agency for Research on Cancer)

  • Lenka Foretova

    (Masaryk Memorial Cancer Institute and MF MU)

  • Marc Maynadie

    (EA 4184, Registre des Hémopathies Malignes de Côte d’Or, University of Burgundy and Dijon University Hospital)

  • James McKay

    (Genetic Cancer Susceptibility Group, Section of Genetics, International Agency for Research on Cancer)

  • Anthony Staines

    (School of Nursing and Human Sciences, Dublin City University)

  • W. Ryan Diver

    (Epidemiology Research Program, American Cancer Society)

  • Claire M. Vajdic

    (Prince of Wales Clinical School, University of New South Wales)

  • Bruce K. Armstrong

    (Sydney School of Public Health, The University of Sydney)

  • Anne Kricker

    (Sydney School of Public Health, The University of Sydney)

  • Tongzhang Zheng

    (Yale School of Public Health)

  • Theodore R. Holford

    (Yale School of Public Health)

  • Gianluca Severi

    (Cancer Epidemiology Centre, Cancer Council Victoria
    Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne
    Human Genetics Foundation)

  • Paolo Vineis

    (MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London
    Human Genetics Foundation)

  • Giovanni M. Ferri

    (University of Bari)

  • Rosalia Ricco

    (University of Bari)

  • Lucia Miligi

    (Environmental and Occupational Epidemiology Unit, Cancer Prevention and Research Institute (ISPO))

  • Jacqueline Clavel

    (Environmental Epidemiology of Cancer Group, Inserm, Centre for research in Epidemiology and Population Health (CESP), U1018
    UMRS 1018, Univ Paris Sud)

  • Edward Giovannucci

    (Brigham and Women’s Hospital and Harvard Medical School
    Harvard School of Public Health
    Harvard School of Public Health)

  • Peter Kraft

    (Harvard School of Public Health
    Harvard School of Public Health)

  • Jarmo Virtamo

    (National Institute for Health and Welfare)

  • Alex Smith

    (University of York)

  • Eleanor Kane

    (University of York)

  • Eve Roman

    (University of York)

  • Brian C. H. Chiu

    (University of Chicago)

  • Joseph F. Fraumeni

    (National Cancer Institute)

  • Xifeng Wu

    (M.D. Anderson Cancer Center)

  • James R. Cerhan

    (Mayo Clinic)

  • Kenneth Offit

    (Memorial Sloan-Kettering Cancer Center)

  • Stephen J. Chanock

    (National Cancer Institute)

  • Nathaniel Rothman

    (National Cancer Institute)

  • Alexandra Nieters

    (Center For Chronic Immunodeficiency, University Medical Center Freiburg)

Abstract

Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10−15) and HLA-B (rs2922994, P=2.43 × 10−9) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.

Suggested Citation

  • Joseph Vijai & Zhaoming Wang & Sonja I. Berndt & Christine F. Skibola & Susan L. Slager & Silvia de Sanjose & Mads Melbye & Bengt Glimelius & Paige M. Bracci & Lucia Conde & Brenda M. Birmann & Sophia, 2015. "A genome-wide association study of marginal zone lymphoma shows association to the HLA region," Nature Communications, Nature, vol. 6(1), pages 1-7, May.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms6751
    DOI: 10.1038/ncomms6751
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    Cited by:

    1. Angela Andaleon & Lauren S Mogil & Heather E Wheeler, 2019. "Genetically regulated gene expression underlies lipid traits in Hispanic cohorts," PLOS ONE, Public Library of Science, vol. 14(8), pages 1-21, August.

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