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Unconventionally secreted effectors of two filamentous pathogens target plant salicylate biosynthesis

Author

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  • Tingli Liu

    (Nanjing Agricultural University
    Provincial Key Laboratory of Agrobiology, Jiangsu Academy of Agricultural Sciences)

  • Tianqiao Song

    (Nanjing Agricultural University)

  • Xiong Zhang

    (Nanjing Agricultural University)

  • Hongbo Yuan

    (Provincial Key Laboratory of Agrobiology, Jiangsu Academy of Agricultural Sciences)

  • Liming Su

    (Nanjing Agricultural University)

  • Wanlin Li

    (Nanjing Agricultural University)

  • Jing Xu

    (Nanjing Agricultural University)

  • Shiheng Liu

    (State Key Laboratory of Microbial Technology, Shandong University)

  • Linlin Chen

    (Nanjing Agricultural University)

  • Tianzi Chen

    (Provincial Key Laboratory of Agrobiology, Jiangsu Academy of Agricultural Sciences)

  • Meixiang Zhang

    (Nanjing Agricultural University)

  • Lichuan Gu

    (State Key Laboratory of Microbial Technology, Shandong University)

  • Baolong Zhang

    (Provincial Key Laboratory of Agrobiology, Jiangsu Academy of Agricultural Sciences)

  • Daolong Dou

    (Nanjing Agricultural University)

Abstract

Plant diseases caused by fungi and oomycetes pose an increasing threat to food security and ecosystem health worldwide. These filamentous pathogens, while taxonomically distinct, modulate host defense responses by secreting effectors, which are typically identified based on the presence of signal peptides. Here we show that Phytophthora sojae and Verticillium dahliae secrete isochorismatases (PsIsc1 and VdIsc1, respectively) that are required for full pathogenesis. PsIsc1 and VdIsc1 can suppress salicylate-mediated innate immunity in planta and hydrolyse isochorismate in vitro. A conserved triad of catalytic residues is essential for both functions. Thus, the two proteins are isochorismatase effectors that disrupt the plant salicylate metabolism pathway by suppressing its precursor. Furthermore, these proteins lack signal peptides, but exhibit characteristics that lead to unconventional secretion. Therefore, this secretion pathway is a novel mechanism for delivering effectors and might play an important role in host–pathogen interactions.

Suggested Citation

  • Tingli Liu & Tianqiao Song & Xiong Zhang & Hongbo Yuan & Liming Su & Wanlin Li & Jing Xu & Shiheng Liu & Linlin Chen & Tianzi Chen & Meixiang Zhang & Lichuan Gu & Baolong Zhang & Daolong Dou, 2014. "Unconventionally secreted effectors of two filamentous pathogens target plant salicylate biosynthesis," Nature Communications, Nature, vol. 5(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5686
    DOI: 10.1038/ncomms5686
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    Cited by:

    1. He Zhu & Yue Li & Xiao-Bin Ji & Dan-Dan Zhang & Jie-Yin Chen & Xiao-Feng Dai & Zi-Sheng Wang & Dan Wang, 2024. "The disease quantification analysis of cotton Verticillium wilt using the two methods of disease index and fungal biomass present high consistency," Plant Protection Science, Czech Academy of Agricultural Sciences, vol. 60(2), pages 161-171.
    2. repec:caa:jnlpps:v:preprint:id:109-2023-pps is not listed on IDEAS

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