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Root-derived CLE glycopeptides control nodulation by direct binding to HAR1 receptor kinase

Author

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  • Satoru Okamoto

    (National Institute for Basic Biology, Nishigonaka 38
    Research Fellow of the Japan Society for the Promotion of Science, 5-3-1 Kojimachi)

  • Hidefumi Shinohara

    (National Institute for Basic Biology, Nishigonaka 38)

  • Tomoko Mori

    (National Institute for Basic Biology, Nishigonaka 38)

  • Yoshikatsu Matsubayashi

    (National Institute for Basic Biology, Nishigonaka 38)

  • Masayoshi Kawaguchi

    (National Institute for Basic Biology, Nishigonaka 38)

Abstract

Leguminous plants establish a symbiosis with rhizobia to enable nitrogen fixation in root nodules under the control of the presumed root-to-shoot-to-root negative feedback called autoregulation of nodulation. In Lotus japonicus, autoregulation is mediated by CLE-RS genes that are specifically expressed in the root, and the receptor kinase HAR1 that functions in the shoot. However, the mature functional structures of CLE-RS gene products and the molecular nature of CLE-RS/HAR1 signalling governed by these spatially distant components remain elusive. Here we show that CLE-RS2 is a post-translationally arabinosylated glycopeptide derived from the CLE domain. Chemically synthesized CLE-RS glycopeptides cause significant suppression of nodulation and directly bind to HAR1 in an arabinose-chain and sequence-dependent manner. In addition, CLE-RS2 glycopeptide specifically produced in the root is found in xylem sap collected from the shoot. We propose that CLE-RS glycopeptides are the long sought mobile signals responsible for the initial step of autoregulation of nodulation.

Suggested Citation

  • Satoru Okamoto & Hidefumi Shinohara & Tomoko Mori & Yoshikatsu Matsubayashi & Masayoshi Kawaguchi, 2013. "Root-derived CLE glycopeptides control nodulation by direct binding to HAR1 receptor kinase," Nature Communications, Nature, vol. 4(1), pages 1-7, October.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3191
    DOI: 10.1038/ncomms3191
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    Cited by:

    1. Moritz Sexauer & Hemal Bhasin & Maria Schön & Elena Roitsch & Caroline Wall & Ulrike Herzog & Katharina Markmann, 2023. "A micro RNA mediates shoot control of root branching," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    2. Jiahuan Chen & Zhijuan Wang & Lixiang Wang & Yangyang Hu & Qiqi Yan & Jingjing Lu & Ziyin Ren & Yujie Hong & Hongtao Ji & Hui Wang & Xinying Wu & Yanru Lin & Chao Su & Thomas Ott & Xia Li, 2022. "The B-type response regulator GmRR11d mediates systemic inhibition of symbiotic nodulation," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Giuseppe Malgioglio & Giulio Flavio Rizzo & Sebastian Nigro & Vincent Lefebvre du Prey & Joelle Herforth-Rahmé & Vittoria Catara & Ferdinando Branca, 2022. "Plant-Microbe Interaction in Sustainable Agriculture: The Factors That May Influence the Efficacy of PGPM Application," Sustainability, MDPI, vol. 14(4), pages 1-28, February.

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