IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v2y2011i1d10.1038_ncomms1432.html
   My bibliography  Save this article

Location-specific patterns of exposure to recent pre-pandemic strains of influenza A in southern China

Author

Listed:
  • Justin Lessler

    (Johns Hopkins Bloomberg School of Public, Health)

  • Derek A.T. Cummings

    (Johns Hopkins Bloomberg School of Public, Health)

  • Jonathan M. Read

    (Institute of Infection and Global Health, University of Liverpool)

  • Shuying Wang

    (Guangzhou No. 12 Hospital)

  • Huachen Zhu

    (International Institute of Infection and Immunity, Shantou University Medical College
    State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong)

  • Gavin J.D. Smith

    (Laboratory of Virus Evolution, Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School)

  • Yi Guan

    (International Institute of Infection and Immunity, Shantou University Medical College
    State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong)

  • Chao Qiang Jiang

    (Guangzhou No. 12 Hospital)

  • Steven Riley

    (Li Ka Shing Faculty of Medicine, The University of Hong Kong)

Abstract

Variation in influenza incidence between locations is commonly observed on large spatial scales. It is unclear whether such variation occurs on smaller spatial scales and whether it is the result of heterogeneities in population demographics or more subtle differences in population structure and connectivity. Here we show that significant differences in immunity to influenza A viruses among communities in China are not explained by differences in population demographics. We randomly selected households from five randomly selected locations near Guangzhou, China to answer a questionnaire and provide a blood sample for serological testing against five recently circulating influenza viruses. We find a significant reduction in the frequency of detectable neutralization titers with increasing age, levelling off in older age groups. There are significant differences between locations in age, employment status, vaccination history, household size and housing conditions. However, after adjustment, significant variations in the frequency of detectable neutralization titers persists between locations. These results suggest there are characteristics of communities that drive influenza transmission dynamics apart from individual and household level risk factors, and that such factors have effects independent of strain.

Suggested Citation

  • Justin Lessler & Derek A.T. Cummings & Jonathan M. Read & Shuying Wang & Huachen Zhu & Gavin J.D. Smith & Yi Guan & Chao Qiang Jiang & Steven Riley, 2011. "Location-specific patterns of exposure to recent pre-pandemic strains of influenza A in southern China," Nature Communications, Nature, vol. 2(1), pages 1-9, September.
    • Handle: RePEc:nat:natcom:v:2:y:2011:i:1:d:10.1038_ncomms1432
    DOI: 10.1038/ncomms1432
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms1432
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms1432?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Justin Lessler & Steven Riley & Jonathan M Read & Shuying Wang & Huachen Zhu & Gavin J D Smith & Yi Guan & Chao Qiang Jiang & Derek A T Cummings, 2012. "Evidence for Antigenic Seniority in Influenza A (H3N2) Antibody Responses in Southern China," PLOS Pathogens, Public Library of Science, vol. 8(7), pages 1-11, July.
    2. Adam J Kucharski & Justin Lessler & Derek A T Cummings & Steven Riley, 2018. "Timescales of influenza A/H3N2 antibody dynamics," PLOS Biology, Public Library of Science, vol. 16(8), pages 1-19, August.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:2:y:2011:i:1:d:10.1038_ncomms1432. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.