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A plant NLR receptor employs ABA central regulator PP2C-SnRK2 to activate antiviral immunity

Author

Listed:
  • Shen Huang

    (Nanjing Agricultural University)

  • Chunli Wang

    (Nanjing Agricultural University)

  • Zixuan Ding

    (Nanjing Agricultural University)

  • Yaqian Zhao

    (Nanjing Agricultural University)

  • Jing Dai

    (Nanjing Agricultural University)

  • Jia Li

    (Nanjing Agricultural University)

  • Haining Huang

    (Nanjing Agricultural University)

  • Tongkai Wang

    (Nanjing Agricultural University)

  • Min Zhu

    (Nanjing Agricultural University)

  • Mingfeng Feng

    (Nanjing Agricultural University)

  • Yinghua Ji

    (Jiangsu Academy of Agricultural Sciences)

  • Zhongkai Zhang

    (National Tobacco Genetic Engineering Research Center)

  • Xiaorong Tao

    (Nanjing Agricultural University)

Abstract

Defence against pathogens relies on intracellular nucleotide-binding, leucine-rich repeat immune receptors (NLRs) in plants. Hormone signaling including abscisic acid (ABA) pathways are activated by NLRs and play pivotal roles in defence against different pathogens. However, little is known about how hormone signaling pathways are activated by plant immune receptors. Here, we report that a plant NLR Sw-5b mimics the behavior of the ABA receptor and directly employs the ABA central regulator PP2C-SnRK2 complex to activate an ABA-dependent defence against viral pathogens. PP2C4 interacts with and constitutively inhibits SnRK2.3/2.4. Behaving in a similar manner as the ABA receptor, pathogen effector ligand recognition triggers the conformational change of Sw-5b NLR that enables binding to PP2C4 via the NB domain. This receptor-PP2C4 binding interferes with the interaction between PP2C4 and SnRK2.3/2.4, thereby releasing SnRK2.3/2.4 from PP2C4 inhibition to activate an ABA-specific antiviral immunity. These findings provide important insights into the activation of hormone signaling pathways by plant immune receptors.

Suggested Citation

  • Shen Huang & Chunli Wang & Zixuan Ding & Yaqian Zhao & Jing Dai & Jia Li & Haining Huang & Tongkai Wang & Min Zhu & Mingfeng Feng & Yinghua Ji & Zhongkai Zhang & Xiaorong Tao, 2024. "A plant NLR receptor employs ABA central regulator PP2C-SnRK2 to activate antiviral immunity," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-47364-8
    DOI: 10.1038/s41467-024-47364-8
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